Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1381844..1382529 Replicon chromosome
Accession NZ_CP038203
Organism Paracoccus pantotrophus strain DSM 11072

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E3U24_RS06870 Protein ID WP_114669535.1
Coordinates 1381844..1382269 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E3U24_RS06875 Protein ID WP_114669536.1
Coordinates 1382266..1382529 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3U24_RS06850 1377785..1377949 - 165 WP_181817364.1 hypothetical protein -
E3U24_RS06855 (E3U24_06795) 1377975..1379312 + 1338 WP_258553475.1 DUF3363 domain-containing protein -
E3U24_RS06860 (E3U24_06800) 1379345..1381354 + 2010 WP_114669533.1 conjugal transfer protein TraG -
E3U24_RS06865 (E3U24_06805) 1381368..1381802 + 435 WP_114669534.1 CopG family transcriptional regulator -
E3U24_RS06870 (E3U24_06810) 1381844..1382269 - 426 WP_114669535.1 type II toxin-antitoxin system VapC family toxin Toxin
E3U24_RS06875 (E3U24_06815) 1382266..1382529 - 264 WP_114669536.1 plasmid stabilization protein Antitoxin
E3U24_RS06885 (E3U24_06825) 1383631..1384128 - 498 WP_024846101.1 Rrf2 family transcriptional regulator -
E3U24_RS06890 (E3U24_06830) 1384273..1385922 + 1650 WP_024846100.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15268.70 Da        Isoelectric Point: 5.1769

>T120803 WP_114669535.1 NZ_CP038203:c1382269-1381844 [Paracoccus pantotrophus]
MILLDTNVVSEPMRDVPNAAVVRWIDAQAIETLHLSTITVAEIRFGIAVLPDGKRKARLHSRFEKEILPLFEDRILPFGL
AASECYASLMAQARGRGTIIGQADGFIAAIAAAVELTVATRDTAPFLAAGIRVINPWDTAD

Download         Length: 426 bp

>T120803 NZ_CP038203:c1382269-1381844 [Paracoccus pantotrophus]
ATGATCCTGCTCGACACGAATGTCGTCTCGGAGCCGATGCGGGATGTCCCGAATGCCGCGGTCGTCCGCTGGATCGATGC
CCAGGCGATCGAGACCCTGCATCTCTCGACCATCACCGTGGCCGAGATCCGGTTCGGCATCGCGGTGCTTCCCGACGGCA
AGCGCAAGGCCCGCCTGCACTCCCGTTTCGAGAAAGAGATCCTGCCGCTCTTCGAGGACCGCATCCTGCCCTTCGGCCTC
GCGGCCTCGGAATGCTACGCAAGCCTGATGGCGCAGGCGCGCGGCAGGGGAACGATCATCGGCCAGGCGGACGGCTTCAT
CGCCGCCATCGCCGCCGCCGTCGAGTTGACCGTCGCGACGCGCGATACCGCGCCGTTCCTGGCTGCCGGCATCAGGGTCA
TCAATCCGTGGGACACGGCGGATTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9859.21 Da        Isoelectric Point: 10.6440

>AT120803 WP_114669536.1 NZ_CP038203:c1382529-1382266 [Paracoccus pantotrophus]
MPAITIRNLSAETHRALKMRAAQHGRSTEAEVRDILEQAARPQNRVRLGSLLAEIGREARMTKEEHALFETAIRRDRTPA
QPIDFGE

Download         Length: 264 bp

>AT120803 NZ_CP038203:c1382529-1382266 [Paracoccus pantotrophus]
ATGCCCGCCATCACCATCCGCAATCTGTCCGCCGAGACGCATCGGGCGCTGAAGATGCGTGCGGCGCAGCATGGGCGCAG
CACCGAAGCCGAAGTGCGCGACATCCTCGAACAGGCGGCGCGACCGCAGAACCGCGTCCGGCTCGGATCCCTGCTGGCCG
AGATCGGCCGTGAAGCGCGGATGACCAAGGAAGAGCACGCCCTGTTCGAGACCGCGATCCGGCGTGACCGGACCCCTGCC
CAACCGATCGATTTCGGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References