Detailed information of TA system TA120802

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 215369..216030
• Replicon: chromosome
• Accession: NZ_CP038203
• Organism: Paracoccus pantotrophus strain DSM 11072

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: E3U24_RS01035
• Protein ID: WP_197029493.1
• Coordinates: 215629..216030 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A495PKQ6
• Locus tag: E3U24_RS01030
• Protein ID: WP_028710954.1
• Coordinates: 215369..215632 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3U24_RS01010 (E3U24_00995)	212433..212816	-	384	WP_028710950.1	hypothetical protein	-
E3U24_RS01015 (E3U24_01000)	212930..213208	-	279	WP_036765876.1	helix-turn-helix domain-containing protein	-
E3U24_RS01020 (E3U24_01005)	213205..213534	-	330	WP_028710952.1	type II toxin-antitoxin system RelE/ParE family toxin	-
E3U24_RS01025 (E3U24_01010)	213631..214983	-	1353	WP_028710953.1	hypothetical protein	-
E3U24_RS01030 (E3U24_01015)	215369..215632	+	264	WP_028710954.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
E3U24_RS01035 (E3U24_01020)	215629..216030	+	402	WP_197029493.1	type II toxin-antitoxin system VapC family toxin	Toxin
E3U24_RS01040 (E3U24_01025)	216120..218558	-	2439	WP_028710956.1	DEAD/DEAH box helicase	-
E3U24_RS01045 (E3U24_01030)	218597..220102	-	1506	WP_114669424.1	TniQ family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	212930..229296	16366

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (16-53)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14092.24 Da
• Isoelectric Point: 5.1698

>T120802 WP_197029493.1 NZ_CP038203:215629-216030 [Paracoccus pantotrophus]
MTLYMLDTNIVSDLLRHPDGSAAKRIAEVGPDAICVSIITAAELRYGCARKGSAKLLAHVEAILESVQILALDVPADAEY
GSIRAELEAAGKPIGPNDLLIAAHACAAGAILVTDNTGEFSRVRGLRVENWIR

Nucleotide

• Length: 402 bp

>T120802 NZ_CP038203:215629-216030 [Paracoccus pantotrophus]
TTGACCCTCTACATGCTCGACACCAATATCGTCTCCGATCTGCTGCGACATCCTGACGGCAGCGCGGCAAAGCGCATTGC
CGAGGTCGGCCCGGATGCGATCTGCGTCAGCATCATCACAGCCGCAGAGCTGAGATATGGGTGCGCCAGGAAAGGGTCTG
CGAAACTCCTGGCGCATGTCGAAGCGATACTGGAAAGCGTGCAGATTCTGGCGCTCGATGTGCCTGCTGACGCGGAATAT
GGCAGCATTCGTGCCGAGCTTGAGGCCGCTGGCAAGCCCATTGGTCCGAACGATCTGCTGATCGCAGCTCATGCCTGCGC
CGCAGGCGCAATCCTCGTGACTGACAATACGGGCGAGTTTTCCCGCGTTCGCGGCCTGCGGGTTGAAAACTGGATCAGGT
AG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9997.39 Da
• Isoelectric Point: 4.8605

>AT120802 WP_028710954.1 NZ_CP038203:215369-215632 [Paracoccus pantotrophus]
MPRPQPHSEPREAKLFRNNKSQAVRIPADFEMPGDRVNIYRDGNRLIIEPVRRKNLLEVLAGLDPLGPEDQFPDVDETLL
PAREIDL

Nucleotide

• Length: 264 bp

>AT120802 NZ_CP038203:215369-215632 [Paracoccus pantotrophus]
ATGCCGCGACCGCAGCCACATTCAGAGCCTCGTGAAGCCAAGCTCTTCCGTAACAACAAGAGCCAGGCCGTCCGCATTCC
CGCAGACTTCGAGATGCCGGGGGATCGGGTGAACATCTATCGTGATGGGAACCGACTTATCATCGAGCCGGTGCGCCGCA
AGAACCTGCTTGAAGTGCTGGCCGGACTAGACCCGCTCGGACCAGAGGATCAGTTTCCTGACGTTGACGAGACGCTTCTC
CCGGCCAGGGAAATCGACCTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A495PKQ6