120801

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2625705..2626390 Replicon chromosome
Accession NZ_CP038197
Organism Paracoccus versutus strain DSM 17099

Toxin (Protein)


Gene name vapC Uniprot ID A0A369U4I2
Locus tag E3U25_RS24390 Protein ID WP_072462939.1
Coordinates 2625705..2626130 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A369U062
Locus tag E3U25_RS24395 Protein ID WP_072462938.1
Coordinates 2626127..2626390 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3U25_RS24375 (E3U25_24210) 2622344..2624344 + 2001 WP_072462941.1 conjugal transfer protein TraG -
E3U25_RS24380 (E3U25_24215) 2624358..2624807 + 450 WP_017998408.1 CopG family transcriptional regulator -
E3U25_RS24385 (E3U25_24220) 2624991..2625368 - 378 WP_072462940.1 hypothetical protein -
E3U25_RS24390 (E3U25_24225) 2625705..2626130 - 426 WP_072462939.1 type II toxin-antitoxin system VapC family toxin Toxin
E3U25_RS24395 (E3U25_24230) 2626127..2626390 - 264 WP_072462938.1 plasmid stabilization protein Antitoxin
E3U25_RS24400 (E3U25_24235) 2626669..2627673 + 1005 WP_072462937.1 P-type conjugative transfer ATPase TrbB -
E3U25_RS24405 (E3U25_24240) 2627670..2628002 + 333 WP_072462936.1 TrbC/VirB2 family protein -
E3U25_RS24410 (E3U25_24245) 2628002..2628283 + 282 WP_072462935.1 VirB3 family type IV secretion system protein -
E3U25_RS24415 (E3U25_24250) 2628296..2630929 + 2634 WP_072462934.1 conjugal transfer protein TrbE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2577164..2627091 49927


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15283.67 Da        Isoelectric Point: 4.7552

>T120801 WP_072462939.1 NZ_CP038197:c2626130-2625705 [Paracoccus versutus]
MILLDTNVVSEPMRDAPDAGVVRWIDEQAIETLHLSAITVAEIRFGIAVLPDGKRKARLHSRFEKEILPLFEDRILPFGL
AASECYASLMAQARGRGTIIGQADGFIAAIAAAVELTVATRDTAPFLAAGITVINPWEEAR

Download         Length: 426 bp

>T120801 NZ_CP038197:c2626130-2625705 [Paracoccus versutus]
ATGATCCTGCTCGACACGAATGTGGTCTCCGAACCGATGCGGGACGCGCCGGATGCCGGAGTCGTCCGCTGGATCGATGA
GCAGGCGATCGAGACTCTGCACCTTTCGGCCATCACCGTGGCCGAGATCCGGTTCGGCATTGCTGTGCTTCCCGACGGCA
AGCGCAAGGCCCGCCTGCATTCCCGTTTCGAGAAAGAGATCCTGCCGCTGTTCGAGGACCGCATCCTGCCCTTCGGTCTC
GCAGCCTCGGAATGCTACGCAAGCCTGATGGCGCAGGCGCGCGGCAGGGGAACGATCATCGGCCAGGCGGACGGCTTCAT
CGCCGCAATCGCCGCCGCCGTCGAGTTGACCGTCGCGACGCGCGATACCGCGCCGTTCCTGGCTGCCGGCATCACCGTCA
TCAATCCATGGGAGGAGGCGAGATGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9931.27 Da        Isoelectric Point: 10.6350

>AT120801 WP_072462938.1 NZ_CP038197:c2626390-2626127 [Paracoccus versutus]
MPAITIRNLSAETHRALKMRAAQHGRSTEAEVRDILEQAARPQNRVRLGSLLAEIGREARMSKEEHALFETAIRRDRTPA
RPIDFDE

Download         Length: 264 bp

>AT120801 NZ_CP038197:c2626390-2626127 [Paracoccus versutus]
ATGCCCGCCATCACCATCCGCAATCTGTCCGCCGAGACGCATCGGGCGCTGAAGATGCGCGCGGCGCAGCATGGGCGCAG
TACCGAGGCCGAAGTGCGCGACATCCTCGAACAGGCAGCGCGACCGCAGAACCGCGTCCGGCTGGGGTCGCTGCTGGCCG
AGATCGGCCGCGAAGCGCGGATGAGCAAGGAAGAGCACGCCCTGTTCGAGACTGCGATCCGGCGTGACCGGACCCCTGCC
CGACCGATCGATTTCGACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A369U4I2

Antitoxin

Source ID Structure
AlphaFold DB A0A369U062

References