Detailed information of TA system TA120799

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1360354..1360883
• Replicon: chromosome
• Accession: NZ_CP038197
• Organism: Paracoccus versutus strain DSM 17099

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: E3U25_RS17950
• Protein ID: WP_116222002.1
• Coordinates: 1360596..1360883 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: E3U25_RS17945
• Protein ID: WP_116222003.1
• Coordinates: 1360354..1360599 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3U25_RS17925 (E3U25_17805)	1355981..1357015	+	1035	WP_036757073.1	alcohol dehydrogenase AdhP	-
E3U25_RS17930 (E3U25_17810)	1357018..1357374	+	357	WP_116222006.1	DUF779 domain-containing protein	-
E3U25_RS17935 (E3U25_17815)	1358038..1358895	+	858	WP_116222005.1	hypothetical protein	-
E3U25_RS17940 (E3U25_17820)	1359068..1360249	+	1182	WP_255469711.1	plasmid recombination protein	-
E3U25_RS17945 (E3U25_17825)	1360354..1360599	+	246	WP_116222003.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
E3U25_RS17950 (E3U25_17830)	1360596..1360883	+	288	WP_116222002.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E3U25_RS17955 (E3U25_17835)	1360951..1361232	+	282	WP_140847660.1	hypothetical protein	-
E3U25_RS17960 (E3U25_17840)	1361452..1362624	-	1173	WP_116222000.1	ATP-binding protein	-
E3U25_RS17965 (E3U25_17845)	1362954..1363163	-	210	WP_116221999.1	hypothetical protein	-
E3U25_RS17970 (E3U25_17850)	1363163..1363669	-	507	WP_116221998.1	hypothetical protein	-
E3U25_RS17975 (E3U25_17855)	1363666..1363848	-	183	WP_116221997.1	hypothetical protein	-
E3U25_RS17980 (E3U25_17860)	1363845..1364141	-	297	WP_244295167.1	zinc ribbon domain-containing protein	-
E3U25_RS17985 (E3U25_17865)	1364275..1364520	+	246	WP_116221996.1	helix-turn-helix transcriptional regulator	-
E3U25_RS17990 (E3U25_17870)	1364564..1364752	+	189	WP_140847657.1	hypothetical protein	-
E3U25_RS17995	1364887..1365039	+	153	WP_166435531.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-90)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10905.39 Da
• Isoelectric Point: 7.2442

>T120799 WP_116222002.1 NZ_CP038197:1360596-1360883 [Paracoccus versutus]
MKALAFTVAATVDLEEVWDYTEREWGLTQARRYVQELRDTCRALASGERRGRKVDVRPGYLKCLSGSHAIFFRDLGDTLE
IVRILHGAQDAERHL

Nucleotide

• Length: 288 bp

>T120799 NZ_CP038197:1360596-1360883 [Paracoccus versutus]
ATGAAGGCGCTGGCCTTCACCGTCGCGGCCACGGTCGATCTGGAGGAAGTCTGGGACTATACGGAACGCGAATGGGGCCT
CACGCAAGCCCGGCGCTATGTGCAGGAGCTGCGCGACACCTGCCGCGCGTTGGCATCGGGTGAAAGGCGCGGCAGGAAAG
TTGACGTTCGGCCGGGCTATCTGAAATGCCTGAGCGGATCGCATGCCATCTTCTTCCGGGATCTGGGCGATACGCTGGAG
ATCGTCCGCATCCTGCACGGCGCGCAGGATGCCGAGCGGCATTTGTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8750.79 Da
• Isoelectric Point: 6.4641

>AT120799 WP_116222003.1 NZ_CP038197:1360354-1360599 [Paracoccus versutus]
MSRNTSVSLGDHFVSFIDAQVKGGRYGSASDVVRAGLRLLEEHEARVKALQDALIAGEDSGRAEGFDLEQFIARKMAGRN
A

Nucleotide

• Length: 246 bp

>AT120799 NZ_CP038197:1360354-1360599 [Paracoccus versutus]
ATGTCCCGCAACACTTCGGTTTCGCTTGGCGATCATTTCGTCAGCTTCATCGACGCGCAGGTGAAGGGCGGTCGCTATGG
CTCGGCCAGCGACGTGGTGCGGGCGGGGCTGCGGCTTCTGGAGGAGCACGAGGCTAGGGTAAAGGCCCTCCAGGACGCCC
TGATCGCCGGAGAGGACTCCGGCCGGGCGGAAGGCTTCGACCTCGAGCAGTTCATTGCTCGCAAGATGGCTGGTCGCAAC
GCATGA