Detailed information of TA system TA120798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 913142..913703
• Replicon: chromosome
• Accession: NZ_CP038197
• Organism: Paracoccus versutus strain DSM 17099

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E3U25_RS15675
• Protein ID: WP_116222242.1
• Coordinates: 913142..913417 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: E3U25_RS15680
• Protein ID: WP_116222455.1
• Coordinates: 913410..913703 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3U25_RS15645	908505..908660	-	156	WP_208861611.1	hypothetical protein	-
E3U25_RS15650 (E3U25_15545)	908844..910298	+	1455	WP_244295116.1	IS21-like element ISPve1 family transposase	-
E3U25_RS15655 (E3U25_15550)	910295..911050	+	756	WP_116220987.1	IS21-like element ISPve1 family helper ATPase IstB	-
E3U25_RS15660	911247..911471	-	225	WP_208861610.1	hypothetical protein	-
E3U25_RS15665	911531..911923	-	393	WP_255469730.1	AIPR family protein	-
E3U25_RS15670	911929..912954	-	1026	WP_208861608.1	AIPR family protein	-
E3U25_RS15675 (E3U25_15560)	913142..913417	-	276	WP_116222242.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E3U25_RS15680 (E3U25_15565)	913410..913703	-	294	WP_116222455.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E3U25_RS15685 (E3U25_15570)	914060..915643	+	1584	WP_244295203.1	tyrosine-type recombinase/integrase	-
E3U25_RS15690 (E3U25_15575)	915715..916920	+	1206	WP_116222241.1	phage portal protein	-
E3U25_RS15695	916913..917047	+	135	WP_263406326.1	hypothetical protein	-
E3U25_RS15700 (E3U25_15580)	917044..917361	+	318	WP_116222240.1	gene transfer agent family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	907364..928478	21114

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-54)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10272.87 Da
• Isoelectric Point: 5.8373

>T120798 WP_116222242.1 NZ_CP038197:c913417-913142 [Paracoccus versutus]
VPEVEWRQAARDDLRSIFEYIADDNPTAALALLDEIEAKVGKLPDRLRAYRPGRVTGTREMVVRPNYLVVYAEVGGALVI
LRVLHAAQMWP

Nucleotide

• Length: 276 bp

>T120798 NZ_CP038197:c913417-913142 [Paracoccus versutus]
GTGCCTGAGGTGGAATGGCGGCAAGCCGCCCGTGACGACCTGCGTTCGATCTTCGAGTACATCGCCGATGACAATCCGAC
AGCGGCACTTGCGCTGCTGGATGAGATCGAGGCAAAGGTTGGCAAGCTGCCTGATCGGCTTAGAGCGTATCGGCCGGGCA
GGGTGACAGGGACACGCGAAATGGTCGTCCGGCCTAACTATCTTGTGGTCTATGCTGAGGTCGGGGGAGCGCTGGTGATC
CTGCGGGTTTTGCATGCGGCGCAGATGTGGCCGTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10735.33 Da
• Isoelectric Point: 7.2052

>AT120798 WP_116222455.1 NZ_CP038197:c913703-913410 [Paracoccus versutus]
MPAQTSMLHVRVDDQLKAQAAEALAGVGLTLSDAVRILLTRVAREGGLPAGLTADPDAYDAWFRAKVREALQDDRPTIRH
ADVMAEMRELIERKRRA

Nucleotide

• Length: 294 bp

>AT120798 NZ_CP038197:c913703-913410 [Paracoccus versutus]
ATGCCCGCACAAACTTCGATGCTGCACGTCCGCGTGGACGACCAACTCAAGGCCCAAGCTGCTGAGGCGCTGGCTGGCGT
CGGCCTGACCCTGTCGGATGCGGTTCGCATCTTGCTGACCCGCGTCGCGCGGGAGGGCGGGTTGCCGGCCGGTTTGACAG
CCGATCCAGATGCCTATGACGCGTGGTTTCGTGCCAAGGTGCGCGAAGCACTTCAGGATGATCGGCCGACGATCCGTCAT
GCCGATGTCATGGCAGAGATGCGCGAACTGATCGAGCGGAAGCGCCGTGCCTGA