Detailed information of TA system TA120797

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1412306..1412914
• Replicon: plasmid pBEN
• Accession: NZ_CP038196
• Organism: Paracoccus versutus strain DSM 17099

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: E3U25_RS07065
• Protein ID: WP_116220801.1
• Coordinates: 1412306..1412494 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: E3U25_RS07070
• Protein ID: WP_116220800.1
• Coordinates: 1412507..1412914 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3U25_RS07025 (E3U25_06985)	1407606..1408328	-	723	WP_166435390.1	hypothetical protein	-
E3U25_RS07030 (E3U25_06990)	1408494..1409135	-	642	WP_116220808.1	hypothetical protein	-
E3U25_RS07035 (E3U25_06995)	1409135..1409704	-	570	WP_116220807.1	hypothetical protein	-
E3U25_RS07040 (E3U25_07000)	1409951..1410571	-	621	WP_116220806.1	DUF1376 domain-containing protein	-
E3U25_RS07045 (E3U25_07005)	1410555..1410785	-	231	WP_116220805.1	hypothetical protein	-
E3U25_RS07050 (E3U25_07010)	1410787..1410984	-	198	WP_147304448.1	hypothetical protein	-
E3U25_RS07055 (E3U25_07015)	1410981..1411682	-	702	WP_116220803.1	hypothetical protein	-
E3U25_RS07060 (E3U25_07020)	1411895..1412125	+	231	WP_116220802.1	hypothetical protein	-
E3U25_RS07065 (E3U25_07025)	1412306..1412494	+	189	WP_116220801.1	type II toxin-antitoxin system HicA family toxin	Toxin
E3U25_RS07070 (E3U25_07030)	1412507..1412914	+	408	WP_116220800.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
E3U25_RS07075 (E3U25_07035)	1412932..1413288	-	357	WP_116220799.1	hypothetical protein	-
E3U25_RS07080	1413285..1413437	-	153	WP_166435389.1	hypothetical protein	-
E3U25_RS07085 (E3U25_07040)	1413437..1413706	-	270	WP_116220798.1	hypothetical protein	-
E3U25_RS07090 (E3U25_07045)	1414034..1414495	+	462	WP_147304447.1	helix-turn-helix transcriptional regulator	-
E3U25_RS07095 (E3U25_07050)	1415064..1415330	+	267	WP_116220795.1	hypothetical protein	-
E3U25_RS07100 (E3U25_07055)	1415327..1415719	+	393	WP_116220794.1	hypothetical protein	-
E3U25_RS07105	1415716..1415880	+	165	WP_166435388.1	hypothetical protein	-
E3U25_RS07110 (E3U25_07060)	1416058..1416258	+	201	WP_072462872.1	hypothetical protein	-
E3U25_RS07115 (E3U25_07065)	1416262..1416588	+	327	WP_116220793.1	hypothetical protein	-
E3U25_RS07120 (E3U25_07070)	1416616..1417467	+	852	WP_116220792.1	DUF2303 family protein	-
E3U25_RS07125 (E3U25_07075)	1417534..1417821	+	288	WP_116220791.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	gmd	1..2238439	2238439

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7238.43 Da
• Isoelectric Point: 11.1468

>T120797 WP_116220801.1 NZ_CP038196:1412306-1412494 [Paracoccus versutus]
MERNSRKLIKMLEADGWVRVAVKGDHWQFKHPEKPGRVTVPHPNKDIKAGTVMSIYRQAGWR

Nucleotide

• Length: 189 bp

>T120797 NZ_CP038196:1412306-1412494 [Paracoccus versutus]
ATGGAACGCAACAGCCGGAAGCTGATCAAGATGCTTGAGGCGGACGGCTGGGTCCGGGTCGCGGTCAAGGGCGATCACTG
GCAGTTCAAGCACCCGGAGAAGCCCGGCCGCGTGACCGTTCCGCACCCGAACAAGGACATCAAGGCCGGCACCGTCATGT
CGATCTATCGACAGGCCGGATGGCGCTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14488.19 Da
• Isoelectric Point: 4.6348

>AT120797 WP_116220800.1 NZ_CP038196:1412507-1412914 [Paracoccus versutus]
MRYVAFLHTDEAGGFGISFPDFPGAISDGDTVEQAIQRGERALAFHVQGMREDGLDVPAPRSVDDILADPDLAEWREGAQ
IAHVALILDRGSPKRVNISLDPGLLDAIDAEAARRGMTRSAFLSSAARAEIHAAH

Nucleotide

• Length: 408 bp

>AT120797 NZ_CP038196:1412507-1412914 [Paracoccus versutus]
ATGCGTTACGTTGCTTTCCTGCACACCGATGAAGCCGGCGGCTTCGGCATCAGCTTTCCCGATTTCCCCGGCGCCATCTC
GGACGGCGACACCGTTGAACAGGCCATCCAGCGCGGCGAGCGGGCACTGGCCTTCCATGTCCAGGGCATGCGCGAGGACG
GCCTCGACGTCCCGGCCCCCCGCAGTGTAGACGACATCCTGGCCGATCCCGACCTTGCCGAATGGCGCGAGGGCGCACAG
ATCGCCCATGTGGCGCTGATTCTGGATCGCGGATCGCCCAAGCGGGTGAACATTTCCCTGGACCCTGGCCTCCTGGACGC
CATCGACGCCGAGGCGGCGCGGCGCGGCATGACGCGCAGCGCGTTCCTGTCCTCGGCCGCGCGCGCGGAAATCCATGCGG
CGCACTGA