Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1412306..1412914 Replicon plasmid pBEN
Accession NZ_CP038196
Organism Paracoccus versutus strain DSM 17099

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E3U25_RS07065 Protein ID WP_116220801.1
Coordinates 1412306..1412494 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E3U25_RS07070 Protein ID WP_116220800.1
Coordinates 1412507..1412914 (+) Length 136 a.a.

Genomic Context

E3U25_RS07060E3U25_RS07065E3U25_RS07070E3U25_RS07090E3U25_RS07095E3U25_RS07100E3U25_RS07105E3U25_RS07110E3U25_RS07115E3U25_RS07120E3U25_RS07125E3U25_RS07025E3U25_RS07030E3U25_RS07035E3U25_RS07040E3U25_RS07045E3U25_RS07050E3U25_RS07055E3U25_RS07075E3U25_RS07080E3U25_RS07085
Location: 1411895..1412125 (231 bp)
Type: Others
Protein ID: WP_116220802.1
Location: 1412306..1412494 (189 bp)
Type: Toxin
Protein ID: WP_116220801.1
Location: 1412507..1412914 (408 bp)
Type: Antitoxin
Protein ID: WP_116220800.1
Location: 1414034..1414495 (462 bp)
Type: Others
Protein ID: WP_147304447.1
Location: 1415064..1415330 (267 bp)
Type: Others
Protein ID: WP_116220795.1
Location: 1415327..1415719 (393 bp)
Type: Others
Protein ID: WP_116220794.1
Location: 1415716..1415880 (165 bp)
Type: Others
Protein ID: WP_166435388.1
Location: 1416058..1416258 (201 bp)
Type: Others
Protein ID: WP_072462872.1
Location: 1416262..1416588 (327 bp)
Type: Others
Protein ID: WP_116220793.1
Location: 1416616..1417467 (852 bp)
Type: Others
Protein ID: WP_116220792.1
Location: 1417534..1417821 (288 bp)
Type: Others
Protein ID: WP_116220791.1
Location: 1407606..1408328 (723 bp)
Type: Others
Protein ID: WP_166435390.1
Location: 1408494..1409135 (642 bp)
Type: Others
Protein ID: WP_116220808.1
Location: 1409135..1409704 (570 bp)
Type: Others
Protein ID: WP_116220807.1
Location: 1409951..1410571 (621 bp)
Type: Others
Protein ID: WP_116220806.1
Location: 1410555..1410785 (231 bp)
Type: Others
Protein ID: WP_116220805.1
Location: 1410787..1410984 (198 bp)
Type: Others
Protein ID: WP_147304448.1
Location: 1410981..1411682 (702 bp)
Type: Others
Protein ID: WP_116220803.1
Location: 1412932..1413288 (357 bp)
Type: Others
Protein ID: WP_116220799.1
Location: 1413285..1413437 (153 bp)
Type: Others
Protein ID: WP_166435389.1
Location: 1413437..1413706 (270 bp)
Type: Others
Protein ID: WP_116220798.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
E3U25_RS07025 (E3U25_06985)1407606..1408328-723WP_166435390.1hypothetical protein-
E3U25_RS07030 (E3U25_06990)1408494..1409135-642WP_116220808.1hypothetical protein-
E3U25_RS07035 (E3U25_06995)1409135..1409704-570WP_116220807.1hypothetical protein-
E3U25_RS07040 (E3U25_07000)1409951..1410571-621WP_116220806.1DUF1376 domain-containing protein-
E3U25_RS07045 (E3U25_07005)1410555..1410785-231WP_116220805.1hypothetical protein-
E3U25_RS07050 (E3U25_07010)1410787..1410984-198WP_147304448.1hypothetical protein-
E3U25_RS07055 (E3U25_07015)1410981..1411682-702WP_116220803.1hypothetical protein-
E3U25_RS07060 (E3U25_07020)1411895..1412125+231WP_116220802.1hypothetical protein-
E3U25_RS07065 (E3U25_07025)1412306..1412494+189WP_116220801.1type II toxin-antitoxin system HicA family toxinToxin
E3U25_RS07070 (E3U25_07030)1412507..1412914+408WP_116220800.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
E3U25_RS07075 (E3U25_07035)1412932..1413288-357WP_116220799.1hypothetical protein-
E3U25_RS070801413285..1413437-153WP_166435389.1hypothetical protein-
E3U25_RS07085 (E3U25_07040)1413437..1413706-270WP_116220798.1hypothetical protein-
E3U25_RS07090 (E3U25_07045)1414034..1414495+462WP_147304447.1helix-turn-helix transcriptional regulator-
E3U25_RS07095 (E3U25_07050)1415064..1415330+267WP_116220795.1hypothetical protein-
E3U25_RS07100 (E3U25_07055)1415327..1415719+393WP_116220794.1hypothetical protein-
E3U25_RS071051415716..1415880+165WP_166435388.1hypothetical protein-
E3U25_RS07110 (E3U25_07060)1416058..1416258+201WP_072462872.1hypothetical protein-
E3U25_RS07115 (E3U25_07065)1416262..1416588+327WP_116220793.1hypothetical protein-
E3U25_RS07120 (E3U25_07070)1416616..1417467+852WP_116220792.1DUF2303 family protein-
E3U25_RS07125 (E3U25_07075)1417534..1417821+288WP_116220791.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid-gmd1..22384392238439


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7238.43 Da        Isoelectric Point: 11.1468

>T120797 WP_116220801.1 NZ_CP038196:1412306-1412494 [Paracoccus versutus]
MERNSRKLIKMLEADGWVRVAVKGDHWQFKHPEKPGRVTVPHPNKDIKAGTVMSIYRQAGWR

Download         Length: 189 bp

>T120797 NZ_CP038196:1412306-1412494 [Paracoccus versutus]
ATGGAACGCAACAGCCGGAAGCTGATCAAGATGCTTGAGGCGGACGGCTGGGTCCGGGTCGCGGTCAAGGGCGATCACTG
GCAGTTCAAGCACCCGGAGAAGCCCGGCCGCGTGACCGTTCCGCACCCGAACAAGGACATCAAGGCCGGCACCGTCATGT
CGATCTATCGACAGGCCGGATGGCGCTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14488.19 Da        Isoelectric Point: 4.6348

>AT120797 WP_116220800.1 NZ_CP038196:1412507-1412914 [Paracoccus versutus]
MRYVAFLHTDEAGGFGISFPDFPGAISDGDTVEQAIQRGERALAFHVQGMREDGLDVPAPRSVDDILADPDLAEWREGAQ
IAHVALILDRGSPKRVNISLDPGLLDAIDAEAARRGMTRSAFLSSAARAEIHAAH

Download         Length: 408 bp

>AT120797 NZ_CP038196:1412507-1412914 [Paracoccus versutus]
ATGCGTTACGTTGCTTTCCTGCACACCGATGAAGCCGGCGGCTTCGGCATCAGCTTTCCCGATTTCCCCGGCGCCATCTC
GGACGGCGACACCGTTGAACAGGCCATCCAGCGCGGCGAGCGGGCACTGGCCTTCCATGTCCAGGGCATGCGCGAGGACG
GCCTCGACGTCCCGGCCCCCCGCAGTGTAGACGACATCCTGGCCGATCCCGACCTTGCCGAATGGCGCGAGGGCGCACAG
ATCGCCCATGTGGCGCTGATTCTGGATCGCGGATCGCCCAAGCGGGTGAACATTTCCCTGGACCCTGGCCTCCTGGACGC
CATCGACGCCGAGGCGGCGCGGCGCGGCATGACGCGCAGCGCGTTCCTGTCCTCGGCCGCGCGCGCGGAAATCCATGCGG
CGCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References