Detailed information of TA system TA120796

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 287656..288686
• Replicon: plasmid pBEN
• Accession: NZ_CP038196
• Organism: Paracoccus versutus strain DSM 17099

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: E3U25_RS01450
• Protein ID: WP_116221565.1
• Coordinates: 287656..288225 (-)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: E3U25_RS01455
• Protein ID: WP_116221566.1
• Coordinates: 288222..288686 (-)
• Length: 155 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3U25_RS01430 (E3U25_01415)	282747..284099	+	1353	WP_166435464.1	ATP-binding protein	-
E3U25_RS01435 (E3U25_01420)	284092..284958	+	867	WP_116221564.1	hypothetical protein	-
E3U25_RS01440 (E3U25_01425)	285038..285793	-	756	WP_116220987.1	IS21-like element ISPve1 family helper ATPase IstB	-
E3U25_RS01445 (E3U25_01430)	285790..287244	-	1455	WP_244295116.1	IS21-like element ISPve1 family transposase	-
E3U25_RS01450 (E3U25_01435)	287656..288225	-	570	WP_116221565.1	PIN domain-containing protein	Toxin
E3U25_RS01455 (E3U25_01440)	288222..288686	-	465	WP_116221566.1	excisionase family DNA-binding protein	Antitoxin
E3U25_RS01460 (E3U25_01445)	288946..290700	-	1755	WP_116221567.1	recombinase family protein	-
E3U25_RS01465 (E3U25_01450)	291244..291543	+	300	WP_116221568.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	gmd	1..2238439	2238439

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-113)

Antitoxin

• Helix-turn-helix domain, group 17 (81-127)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 21031.10 Da
• Isoelectric Point: 5.0484

>T120796 WP_116221565.1 NZ_CP038196:c288225-287656 [Paracoccus versutus]
MSRYTALLDANVLYPAPLRDLLLQLAVTDLFRARWTADIHREWIEALLRNEPGRDRAALERTRDLMDRATRDSLVEGYHA
LIPALELPDADDRHVLAAAIIGRCDVIVTQNLADFPAEALASFGIDVQHPDEFLVNHLHLAPGLFCASIRKVRARLRNPP
YSVEDYLGTLTQIGLVATAAELGGFAELL

Nucleotide

• Length: 570 bp

>T120796 NZ_CP038196:c288225-287656 [Paracoccus versutus]
ATGAGCCGTTACACCGCTCTGCTGGATGCGAATGTCCTCTATCCCGCGCCGCTGCGGGATCTGTTGTTGCAACTGGCCGT
CACCGATCTGTTCAGGGCGCGCTGGACGGCCGACATCCATCGCGAATGGATCGAGGCGCTGCTGCGCAACGAACCGGGGC
GGGACCGCGCCGCGCTGGAACGCACCCGCGACCTGATGGACCGGGCTACGCGCGACAGCCTGGTCGAGGGCTACCACGCA
CTGATCCCGGCGCTGGAACTACCGGATGCCGATGACCGGCATGTGCTGGCTGCCGCCATCATCGGGCGTTGCGACGTGAT
CGTGACCCAGAATCTGGCCGACTTCCCGGCCGAGGCGCTGGCGTCGTTTGGCATCGACGTGCAGCACCCGGACGAATTCC
TGGTCAACCACCTGCACCTCGCGCCCGGCCTGTTCTGTGCTTCCATCCGCAAGGTGCGCGCCCGGCTGAGGAACCCGCCT
TATAGCGTCGAGGATTATCTCGGCACCCTGACGCAGATCGGGCTAGTCGCCACAGCGGCCGAGCTCGGCGGGTTTGCCGA
GCTACTTTGA

Antitoxin

Protein

• Length: 155 a.a.
• Molecular weight: 17121.84 Da
• Isoelectric Point: 7.3206

>AT120796 WP_116221566.1 NZ_CP038196:c288686-288222 [Paracoccus versutus]
MTMLAHRQLPPSAQDAAIARVSGQLLSRYARQKRPLTLRVTDAEQERPLELPAGAVALLMDILEAMAAGRGVTLMPENAE
LTTVQAAEVLNVSRPFLIKLLDESAIPHRKVGKHRRIRMEDVMAYKAAIDREREAVLDQLVSEAQEQDMGYGRP

Nucleotide

• Length: 465 bp

>AT120796 NZ_CP038196:c288686-288222 [Paracoccus versutus]
ATGACCATGCTAGCCCATCGACAGCTTCCGCCCTCGGCGCAGGATGCCGCGATTGCGCGCGTGTCCGGCCAGCTTCTGTC
CCGCTATGCCCGTCAGAAGCGGCCACTGACCCTGCGCGTCACCGATGCCGAACAGGAACGCCCGCTGGAACTCCCTGCCG
GGGCGGTCGCCCTGCTGATGGACATCCTGGAGGCAATGGCCGCCGGGCGCGGCGTCACCCTCATGCCCGAGAACGCGGAA
CTGACCACAGTGCAGGCCGCCGAGGTGCTGAACGTCTCGCGCCCATTCCTCATCAAGCTGCTGGACGAAAGCGCGATCCC
GCACCGCAAGGTCGGCAAGCATCGCCGCATCCGCATGGAAGACGTGATGGCCTACAAGGCCGCCATCGACCGCGAACGCG
AGGCCGTGCTCGACCAGCTTGTCAGCGAGGCGCAGGAACAGGATATGGGCTACGGCCGCCCATGA