Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2129401..2129915 Replicon chromosome
Accession NZ_CP038183
Organism Staphylococcus aureus strain MJ015

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag E3306_RS10530 Protein ID WP_000581793.1
Coordinates 2129401..2129610 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag E3306_RS10535 Protein ID WP_000138932.1
Coordinates 2129622..2129915 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3306_RS10510 2124910..2126268 - 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
E3306_RS10515 2126283..2127353 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
E3306_RS10520 2127671..2128873 + 1203 WP_001109939.1 rod shape-determining protein RodA -
E3306_RS10525 2129136..2129273 - 138 WP_000828354.1 hypothetical protein -
E3306_RS10530 2129401..2129610 - 210 WP_000581793.1 heavy-metal-associated domain-containing protein Toxin
E3306_RS10535 2129622..2129915 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3306_RS10540 2130081..2131565 + 1485 WP_000571552.1 cardiolipin synthase -
E3306_RS10545 2131593..2132240 + 648 WP_001187627.1 HD domain-containing protein -
E3306_RS10550 2132952..2133824 - 873 WP_000725802.1 membrane protein insertase YidC -
E3306_RS10555 2133910..2134551 - 642 WP_000483164.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T120784 WP_000581793.1 NZ_CP038183:c2129610-2129401 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T120784 NZ_CP038183:c2129610-2129401 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT120784 WP_000138932.1 NZ_CP038183:c2129915-2129622 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT120784 NZ_CP038183:c2129915-2129622 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References