Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1068147..1068935 Replicon chromosome
Accession NZ_CP038183
Organism Staphylococcus aureus strain MJ015

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag E3306_RS05135 Protein ID WP_000525004.1
Coordinates 1068147..1068608 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag E3306_RS05140 Protein ID WP_000333630.1
Coordinates 1068621..1068935 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3306_RS05110 1063564..1064703 - 1140 WP_000843620.1 nucleotidyltransferase -
E3306_RS05115 1064830..1065387 + 558 WP_000872158.1 DUF177 domain-containing protein -
E3306_RS05120 1065467..1065640 + 174 WP_000290472.1 50S ribosomal protein L32 -
E3306_RS05125 1065757..1067142 - 1386 WP_000861313.1 recombinase family protein -
E3306_RS05130 1067200..1068129 - 930 WP_001253415.1 DUF5067 domain-containing protein -
E3306_RS05135 1068147..1068608 - 462 WP_000525004.1 hypothetical protein Toxin
E3306_RS05140 1068621..1068935 - 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
E3306_RS05145 1069087..1069323 + 237 WP_001121027.1 helix-turn-helix domain-containing protein -
E3306_RS05150 1069337..1070113 + 777 WP_031783556.1 Rha family transcriptional regulator -
E3306_RS05155 1070142..1070309 + 168 WP_162852001.1 hypothetical protein -
E3306_RS05160 1070360..1070842 - 483 WP_033858402.1 hypothetical protein -
E3306_RS05165 1071052..1071282 - 231 WP_000395457.1 hypothetical protein -
E3306_RS05170 1071462..1071623 + 162 WP_000066026.1 DUF1270 family protein -
E3306_RS05175 1071717..1071977 + 261 WP_064127680.1 DUF1108 family protein -
E3306_RS05180 1071986..1072249 + 264 WP_001205732.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1065757..1107871 42114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T120778 WP_000525004.1 NZ_CP038183:c1068608-1068147 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T120778 NZ_CP038183:c1068608-1068147 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT120778 WP_000333630.1 NZ_CP038183:c1068935-1068621 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT120778 NZ_CP038183:c1068935-1068621 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References