Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 826116..826593 Replicon chromosome
Accession NZ_CP038183
Organism Staphylococcus aureus strain MJ015

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3306_RS03915 Protein ID WP_000052076.1
Coordinates 826116..826304 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3306_RS03920 Protein ID WP_001059690.1
Coordinates 826333..826593 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3306_RS03885 822119..822628 + 510 WP_000824480.1 hypothetical protein -
E3306_RS03890 822969..823655 + 687 WP_001641381.1 thermonuclease family protein -
E3306_RS03895 824012..824212 + 201 WP_001059082.1 cold-shock protein -
E3306_RS03900 824707..824925 - 219 WP_000005889.1 hypothetical protein -
E3306_RS03905 824987..825271 - 285 WP_001004395.1 hypothetical protein -
E3306_RS03910 825359..825928 - 570 WP_001106654.1 hypothetical protein -
E3306_RS03915 826116..826304 - 189 WP_000052076.1 hypothetical protein Toxin
E3306_RS03920 826333..826593 - 261 WP_001059690.1 hypothetical protein Antitoxin
E3306_RS03925 826933..827136 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3306_RS03930 827133..827369 - 237 WP_000368687.1 hypothetical protein -
E3306_RS03935 827594..828175 + 582 WP_001140690.1 phosphoglycerate mutase family protein -
E3306_RS03940 828248..828865 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
E3306_RS03945 829019..829513 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3306_RS03950 829912..830334 - 423 WP_000974447.1 organic hydroperoxide resistance protein -
E3306_RS03955 830482..831198 + 717 WP_000150021.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T120777 WP_000052076.1 NZ_CP038183:c826304-826116 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T120777 NZ_CP038183:c826304-826116 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT120777 WP_001059690.1 NZ_CP038183:c826593-826333 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT120777 NZ_CP038183:c826593-826333 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References