Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-yefM/Txe-RelB |
Location | 1342884..1343413 | Replicon | chromosome |
Accession | NZ_CP038177 | ||
Organism | Enterococcus faecium strain HN11 |
Toxin (Protein)
Gene name | relE | Uniprot ID | C9B8W9 |
Locus tag | E3O58_RS06940 | Protein ID | WP_002294198.1 |
Coordinates | 1342884..1343150 (-) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | C9B8W8 |
Locus tag | E3O58_RS06945 | Protein ID | WP_002294199.1 |
Coordinates | 1343150..1343413 (-) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E3O58_RS06915 (E3O58_07245) | 1338250..1339425 | + | 1176 | WP_265460815.1 | betaine/proline/choline family ABC transporter ATP-binding protein | - |
E3O58_RS06920 (E3O58_07250) | 1339429..1340070 | + | 642 | WP_002293405.1 | ABC transporter permease | - |
E3O58_RS06925 (E3O58_07255) | 1340067..1340985 | + | 919 | Protein_1276 | osmoprotectant ABC transporter substrate-binding protein | - |
E3O58_RS06930 (E3O58_07260) | 1341000..1341653 | + | 654 | WP_002317081.1 | ABC transporter permease | - |
E3O58_RS06935 (E3O58_07265) | 1342195..1342683 | - | 489 | WP_002294196.1 | mannosyl-glycoprotein endo-beta-N-acetylglucosamidase | - |
E3O58_RS06940 (E3O58_07270) | 1342884..1343150 | - | 267 | WP_002294198.1 | Txe/YoeB family addiction module toxin | Toxin |
E3O58_RS06945 (E3O58_07275) | 1343150..1343413 | - | 264 | WP_002294199.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
E3O58_RS06950 | 1343753..1343878 | - | 126 | WP_002348886.1 | hypothetical protein | - |
E3O58_RS06955 (E3O58_07285) | 1343888..1344073 | + | 186 | WP_002294201.1 | hypothetical protein | - |
E3O58_RS06960 (E3O58_07290) | 1344215..1346038 | - | 1824 | WP_002294202.1 | APC family permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10646.11 Da Isoelectric Point: 9.9931
>T120748 WP_002294198.1 NZ_CP038177:c1343150-1342884 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE
Download Length: 267 bp
>T120748 NZ_CP038177:c1343150-1342884 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 10016.03 Da Isoelectric Point: 4.1207
>AT120748 WP_002294199.1 NZ_CP038177:c1343413-1343150 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL
Download Length: 264 bp
>AT120748 NZ_CP038177:c1343413-1343150 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGATGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGATGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829FMA0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZU84 |