Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 1342884..1343413 Replicon chromosome
Accession NZ_CP038177
Organism Enterococcus faecium strain HN11

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag E3O58_RS06940 Protein ID WP_002294198.1
Coordinates 1342884..1343150 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag E3O58_RS06945 Protein ID WP_002294199.1
Coordinates 1343150..1343413 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3O58_RS06915 (E3O58_07245) 1338250..1339425 + 1176 WP_265460815.1 betaine/proline/choline family ABC transporter ATP-binding protein -
E3O58_RS06920 (E3O58_07250) 1339429..1340070 + 642 WP_002293405.1 ABC transporter permease -
E3O58_RS06925 (E3O58_07255) 1340067..1340985 + 919 Protein_1276 osmoprotectant ABC transporter substrate-binding protein -
E3O58_RS06930 (E3O58_07260) 1341000..1341653 + 654 WP_002317081.1 ABC transporter permease -
E3O58_RS06935 (E3O58_07265) 1342195..1342683 - 489 WP_002294196.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
E3O58_RS06940 (E3O58_07270) 1342884..1343150 - 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
E3O58_RS06945 (E3O58_07275) 1343150..1343413 - 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3O58_RS06950 1343753..1343878 - 126 WP_002348886.1 hypothetical protein -
E3O58_RS06955 (E3O58_07285) 1343888..1344073 + 186 WP_002294201.1 hypothetical protein -
E3O58_RS06960 (E3O58_07290) 1344215..1346038 - 1824 WP_002294202.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T120748 WP_002294198.1 NZ_CP038177:c1343150-1342884 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T120748 NZ_CP038177:c1343150-1342884 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT120748 WP_002294199.1 NZ_CP038177:c1343413-1343150 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT120748 NZ_CP038177:c1343413-1343150 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGATGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References