Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Fic-hicB/Fic-HicB |
| Location | 1204..2351 | Replicon | plasmid pSDGJQ5 |
| Accession | NZ_CP038175 | ||
| Organism | Enterococcus faecium strain SDGJQ5 | ||
Toxin (Protein)
| Gene name | Fic | Uniprot ID | Q9AL00 |
| Locus tag | E3T52_RS13150 | Protein ID | WP_000599739.1 |
| Coordinates | 1746..2351 (+) | Length | 202 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A7G7IUL1 |
| Locus tag | E3T52_RS13145 | Protein ID | WP_002359626.1 |
| Coordinates | 1204..1635 (+) | Length | 144 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3T52_RS13130 (E3T52_13780) | 499..699 | + | 201 | WP_002359624.1 | hypothetical protein | - |
| E3T52_RS13135 (E3T52_13785) | 715..894 | + | 180 | WP_002295613.1 | hypothetical protein | - |
| E3T52_RS13140 (E3T52_13790) | 987..1170 | + | 184 | Protein_3 | type II toxin-antitoxin system HicA family toxin | - |
| E3T52_RS13145 (E3T52_13795) | 1204..1635 | + | 432 | WP_002359626.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| E3T52_RS13150 (E3T52_13800) | 1746..2351 | + | 606 | WP_000599739.1 | Fic family protein | Toxin |
| E3T52_RS13155 (E3T52_13805) | 2367..2939 | + | 573 | WP_000170424.1 | recombinase family protein | - |
| E3T52_RS13160 (E3T52_13810) | 3372..4331 | - | 960 | WP_000222577.1 | IS30-like element IS1252 family transposase | - |
| E3T52_RS13165 (E3T52_13815) | 4459..5139 | - | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
| E3T52_RS13170 (E3T52_13820) | 5193..6821 | - | 1629 | WP_002415638.1 | ABC-F type ribosomal protection protein PoxtA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 202 a.a. Molecular weight: 23506.86 Da Isoelectric Point: 4.6428
>T120744 WP_000599739.1 NZ_CP038175:1746-2351 [Enterococcus faecium]
MILENKLGLTNQVELAKVEEKLSKQKAKELYDCGKINEIEVGTFKGLSEIHEFLFSDIYDFAGKIRSVNIAKGNFRFAPV
MYLEHSLQHIDQMPQTSFEEIIKKYVEMNIAHPFREGNGRSTRIWLDLILKEELQKVVDWNLIDKADYLSAMERSPINDL
EIRYLISNALTDKIDDRELYMKGIDVSYFYEGYSEYTIDDL
MILENKLGLTNQVELAKVEEKLSKQKAKELYDCGKINEIEVGTFKGLSEIHEFLFSDIYDFAGKIRSVNIAKGNFRFAPV
MYLEHSLQHIDQMPQTSFEEIIKKYVEMNIAHPFREGNGRSTRIWLDLILKEELQKVVDWNLIDKADYLSAMERSPINDL
EIRYLISNALTDKIDDRELYMKGIDVSYFYEGYSEYTIDDL
Download Length: 606 bp
>T120744 NZ_CP038175:1746-2351 [Enterococcus faecium]
ATGATTTTAGAGAATAAATTGGGATTAACCAATCAAGTTGAGTTGGCTAAGGTTGAAGAAAAACTCAGTAAACAAAAAGC
GAAAGAATTGTACGATTGTGGAAAAATAAATGAAATCGAAGTTGGTACATTTAAAGGTTTATCTGAAATTCATGAATTTC
TATTTTCGGATATTTACGATTTTGCCGGAAAAATCCGATCGGTCAATATTGCAAAAGGAAATTTTCGATTTGCACCAGTT
ATGTATTTAGAACATTCGTTACAGCATATTGATCAGATGCCACAAACTTCTTTTGAAGAGATTATCAAGAAATATGTGGA
GATGAATATCGCTCACCCATTTCGAGAAGGAAATGGCCGAAGTACTAGAATTTGGCTGGATCTCATTTTAAAGGAAGAAT
TGCAAAAAGTTGTAGATTGGAACTTAATCGATAAAGCAGACTATCTTTCTGCAATGGAGCGAAGTCCCATAAACGATTTG
GAAATACGCTATCTAATTTCCAATGCTCTGACTGATAAAATTGACGATCGCGAGTTATATATGAAAGGAATCGATGTCAG
CTATTTCTATGAAGGGTATTCTGAGTATACGATAGATGATTTGTAA
ATGATTTTAGAGAATAAATTGGGATTAACCAATCAAGTTGAGTTGGCTAAGGTTGAAGAAAAACTCAGTAAACAAAAAGC
GAAAGAATTGTACGATTGTGGAAAAATAAATGAAATCGAAGTTGGTACATTTAAAGGTTTATCTGAAATTCATGAATTTC
TATTTTCGGATATTTACGATTTTGCCGGAAAAATCCGATCGGTCAATATTGCAAAAGGAAATTTTCGATTTGCACCAGTT
ATGTATTTAGAACATTCGTTACAGCATATTGATCAGATGCCACAAACTTCTTTTGAAGAGATTATCAAGAAATATGTGGA
GATGAATATCGCTCACCCATTTCGAGAAGGAAATGGCCGAAGTACTAGAATTTGGCTGGATCTCATTTTAAAGGAAGAAT
TGCAAAAAGTTGTAGATTGGAACTTAATCGATAAAGCAGACTATCTTTCTGCAATGGAGCGAAGTCCCATAAACGATTTG
GAAATACGCTATCTAATTTCCAATGCTCTGACTGATAAAATTGACGATCGCGAGTTATATATGAAAGGAATCGATGTCAG
CTATTTCTATGAAGGGTATTCTGAGTATACGATAGATGATTTGTAA
Antitoxin
Download Length: 144 a.a. Molecular weight: 15809.95 Da Isoelectric Point: 4.1719
>AT120744 WP_002359626.1 NZ_CP038175:1204-1635 [Enterococcus faecium]
MLSEPLAKTYPAIFSPEEGGGYFIEFPDVQGAYTGINEDDISYGIAMAQEVLGMVLADYIEHEELLPEPTPINKIAVEDD
SFTTLIRVDVAKYLKDTELVKKTLTIPQWADKLGKRAGINFSVLLTESIADKADNILRSGRNN
MLSEPLAKTYPAIFSPEEGGGYFIEFPDVQGAYTGINEDDISYGIAMAQEVLGMVLADYIEHEELLPEPTPINKIAVEDD
SFTTLIRVDVAKYLKDTELVKKTLTIPQWADKLGKRAGINFSVLLTESIADKADNILRSGRNN
Download Length: 432 bp
>AT120744 NZ_CP038175:1204-1635 [Enterococcus faecium]
ATGTTAAGTGAGCCTTTAGCAAAAACCTATCCTGCTATTTTTAGCCCAGAAGAAGGTGGTGGGTACTTTATTGAATTTCC
TGATGTTCAAGGTGCTTACACAGGAATTAACGAAGACGATATATCTTATGGAATTGCTATGGCACAAGAGGTTTTAGGTA
TGGTTTTAGCAGATTATATTGAGCATGAAGAGCTACTTCCAGAACCAACACCAATCAATAAGATCGCTGTTGAAGATGAT
TCTTTTACTACTTTAATTCGTGTAGATGTTGCCAAATATTTGAAAGACACAGAACTTGTCAAAAAAACCTTAACAATTCC
TCAATGGGCGGATAAGTTAGGCAAAAGGGCTGGCATAAATTTTTCAGTCCTTCTAACAGAATCAATTGCAGATAAAGCAG
ATAACATTCTTCGTTCTGGAAGAAATAATTAG
ATGTTAAGTGAGCCTTTAGCAAAAACCTATCCTGCTATTTTTAGCCCAGAAGAAGGTGGTGGGTACTTTATTGAATTTCC
TGATGTTCAAGGTGCTTACACAGGAATTAACGAAGACGATATATCTTATGGAATTGCTATGGCACAAGAGGTTTTAGGTA
TGGTTTTAGCAGATTATATTGAGCATGAAGAGCTACTTCCAGAACCAACACCAATCAATAAGATCGCTGTTGAAGATGAT
TCTTTTACTACTTTAATTCGTGTAGATGTTGCCAAATATTTGAAAGACACAGAACTTGTCAAAAAAACCTTAACAATTCC
TCAATGGGCGGATAAGTTAGGCAAAAGGGCTGGCATAAATTTTTCAGTCCTTCTAACAGAATCAATTGCAGATAAAGCAG
ATAACATTCTTCGTTCTGGAAGAAATAATTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A828ZHD6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7G7IUL1 |