Detailed information of TA system TA120743

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/Txe-RelB
• Location: 1737223..1737752
• Replicon: chromosome
• Accession: NZ_CP038174
• Organism: Enterococcus faecium strain SDGJQ5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E3T52_RS08485
• Protein ID: WP_283657014.1
• Coordinates: 1737223..1737489 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: C9B8W8
• Locus tag: E3T52_RS08490
• Protein ID: WP_002294199.1
• Coordinates: 1737489..1737752 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T52_RS08455 (E3T52_08870)	1732590..1733765	+	1176	WP_002294192.1	betaine/proline/choline family ABC transporter ATP-binding protein	-
E3T52_RS08460 (E3T52_08875)	1733769..1734410	+	642	WP_002293405.1	ABC transporter permease	-
E3T52_RS08465 (E3T52_08880)	1734407..1735324	+	918	WP_002294193.1	osmoprotectant ABC transporter substrate-binding protein	-
E3T52_RS08470 (E3T52_08885)	1735321..1735992	+	672	WP_002319469.1	ABC transporter permease	-
E3T52_RS08475	1736304..1736471	-	168	WP_002294195.1	hypothetical protein	-
E3T52_RS08480 (E3T52_08890)	1736534..1737022	-	489	WP_002294196.1	mannosyl-glycoprotein endo-beta-N-acetylglucosamidase	-
E3T52_RS08485 (E3T52_08895)	1737223..1737489	-	267	WP_283657014.1	Txe/YoeB family addiction module toxin	Toxin
E3T52_RS08490 (E3T52_08900)	1737489..1737752	-	264	WP_002294199.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E3T52_RS08495	1738092..1738220	-	129	WP_002294200.1	hypothetical protein	-
E3T52_RS08500 (E3T52_08910)	1738227..1738412	+	186	WP_002294201.1	hypothetical protein	-
E3T52_RS08505 (E3T52_08915)	1738554..1740377	-	1824	WP_002294202.1	APC family permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (22-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (5-69)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10676.13 Da
• Isoelectric Point: 9.9931

>T120743 WP_283657014.1 NZ_CP038174:c1737489-1737223 [Enterococcus faecium]
MSNYTVAIKNSTKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Nucleotide

• Length: 267 bp

>T120743 NZ_CP038174:c1737489-1737223 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTACGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10016.03 Da
• Isoelectric Point: 4.1207

>AT120743 WP_002294199.1 NZ_CP038174:c1737752-1737489 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Nucleotide

• Length: 264 bp

>AT120743 NZ_CP038174:c1737752-1737489 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A828ZU84