Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 517720..518249 Replicon chromosome
Accession NZ_CP038172
Organism Enterococcus faecium strain YN2-1

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag E3T57_RS02490 Protein ID WP_002294198.1
Coordinates 517720..517986 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag E3T57_RS02495 Protein ID WP_002294199.1
Coordinates 517986..518249 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T57_RS02460 (E3T57_02660) 513087..514262 + 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -
E3T57_RS02465 (E3T57_02665) 514266..514907 + 642 WP_002293405.1 ABC transporter permease -
E3T57_RS02470 (E3T57_02670) 514904..515821 + 918 WP_002294193.1 osmoprotectant ABC transporter substrate-binding protein -
E3T57_RS02475 (E3T57_02675) 515818..516489 + 672 WP_002319469.1 ABC transporter permease -
E3T57_RS02480 516801..516968 - 168 WP_002294195.1 hypothetical protein -
E3T57_RS02485 (E3T57_02680) 517031..517519 - 489 WP_002294196.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
E3T57_RS02490 (E3T57_02685) 517720..517986 - 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
E3T57_RS02495 (E3T57_02690) 517986..518249 - 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3T57_RS02500 518589..518717 - 129 WP_002294200.1 hypothetical protein -
E3T57_RS02505 (E3T57_02700) 518724..518909 + 186 WP_002294201.1 hypothetical protein -
E3T57_RS02510 (E3T57_02705) 519051..520874 - 1824 WP_002294202.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T120741 WP_002294198.1 NZ_CP038172:c517986-517720 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T120741 NZ_CP038172:c517986-517720 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT120741 WP_002294199.1 NZ_CP038172:c518249-517986 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT120741 NZ_CP038172:c518249-517986 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References