Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2151930..2152459 Replicon chromosome
Accession NZ_CP038170
Organism Enterococcus faecium strain SDGJP3

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag E3T45_RS10725 Protein ID WP_002294198.1
Coordinates 2152193..2152459 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag E3T45_RS10720 Protein ID WP_002294199.1
Coordinates 2151930..2152193 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T45_RS10710 (E3T45_11265) 2149421..2151128 + 1708 Protein_2052 APC family permease -
E3T45_RS10715 (E3T45_11270) 2151270..2151455 - 186 WP_002294201.1 hypothetical protein -
E3T45_RS10720 (E3T45_11280) 2151930..2152193 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3T45_RS10725 (E3T45_11285) 2152193..2152459 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
E3T45_RS10730 (E3T45_11290) 2152660..2153148 + 489 WP_002328659.1 hypothetical protein -
E3T45_RS10735 (E3T45_11295) 2153690..2154361 - 672 WP_002319469.1 ABC transporter permease -
E3T45_RS10740 (E3T45_11300) 2154358..2155275 - 918 WP_002301114.1 osmoprotectant ABC transporter substrate-binding protein -
E3T45_RS10745 (E3T45_11305) 2155272..2155913 - 642 WP_002293405.1 ABC transporter permease -
E3T45_RS10750 (E3T45_11310) 2155917..2157092 - 1176 WP_002328660.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T120738 WP_002294198.1 NZ_CP038170:2152193-2152459 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T120738 NZ_CP038170:2152193-2152459 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT120738 WP_002294199.1 NZ_CP038170:2151930-2152193 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT120738 NZ_CP038170:2151930-2152193 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACAGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References