Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 1838260..1838789 Replicon chromosome
Accession NZ_CP038166
Organism Enterococcus faecium strain SC3-1

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag E3O61_RS09000 Protein ID WP_002294198.1
Coordinates 1838523..1838789 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag E3O61_RS08995 Protein ID WP_002294199.1
Coordinates 1838260..1838523 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3O61_RS08980 (E3O61_09385) 1835635..1837458 + 1824 WP_002294202.1 APC family permease -
E3O61_RS08985 (E3O61_09390) 1837600..1837785 - 186 WP_002294201.1 hypothetical protein -
E3O61_RS08990 1837792..1837920 + 129 WP_002294200.1 hypothetical protein -
E3O61_RS08995 (E3O61_09400) 1838260..1838523 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3O61_RS09000 (E3O61_09405) 1838523..1838789 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
E3O61_RS09005 (E3O61_09410) 1838990..1839478 + 489 WP_002294196.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
E3O61_RS09010 (E3O61_09415) 1840020..1840691 - 672 WP_002319469.1 ABC transporter permease -
E3O61_RS09015 (E3O61_09420) 1840688..1841605 - 918 WP_002294193.1 osmoprotectant ABC transporter substrate-binding protein -
E3O61_RS09020 (E3O61_09425) 1841602..1842243 - 642 WP_002293405.1 ABC transporter permease -
E3O61_RS09025 (E3O61_09430) 1842247..1843422 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1843614..1844264 650


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T120736 WP_002294198.1 NZ_CP038166:1838523-1838789 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T120736 NZ_CP038166:1838523-1838789 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT120736 WP_002294199.1 NZ_CP038166:1838260-1838523 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT120736 NZ_CP038166:1838260-1838523 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References