Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 1446053..1446582 Replicon chromosome
Accession NZ_CP038164
Organism Enterococcus faecium strain HB2-2

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag E3O52_RS06845 Protein ID WP_002294198.1
Coordinates 1446053..1446319 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag E3O52_RS06850 Protein ID WP_002294199.1
Coordinates 1446319..1446582 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3O52_RS06820 (E3O52_07165) 1441420..1442595 + 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -
E3O52_RS06825 (E3O52_07170) 1442599..1443240 + 642 WP_002293405.1 ABC transporter permease -
E3O52_RS06830 (E3O52_07175) 1443237..1444154 + 918 WP_002294193.1 osmoprotectant ABC transporter substrate-binding protein -
E3O52_RS06835 (E3O52_07180) 1444151..1444822 + 672 WP_002319469.1 ABC transporter permease -
E3O52_RS06840 (E3O52_07185) 1445364..1445852 - 489 WP_002294196.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
E3O52_RS06845 (E3O52_07190) 1446053..1446319 - 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
E3O52_RS06850 (E3O52_07195) 1446319..1446582 - 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3O52_RS06855 1446922..1447050 - 129 WP_002294200.1 hypothetical protein -
E3O52_RS06860 (E3O52_07205) 1447057..1447242 + 186 WP_002294201.1 hypothetical protein -
E3O52_RS06865 (E3O52_07210) 1447384..1449207 - 1824 WP_002294202.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T120735 WP_002294198.1 NZ_CP038164:c1446319-1446053 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T120735 NZ_CP038164:c1446319-1446053 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT120735 WP_002294199.1 NZ_CP038164:c1446582-1446319 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT120735 NZ_CP038164:c1446582-1446319 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References