Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 1237434..1237963 Replicon chromosome
Accession NZ_CP038163
Organism Enterococcus faecium strain GZ8

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag E3O43_RS06140 Protein ID WP_002294198.1
Coordinates 1237434..1237700 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag E3O43_RS06145 Protein ID WP_002294199.1
Coordinates 1237700..1237963 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3O43_RS06115 (E3O43_06465) 1232801..1233976 + 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -
E3O43_RS06120 (E3O43_06470) 1233980..1234621 + 642 WP_002293405.1 ABC transporter permease -
E3O43_RS06125 (E3O43_06475) 1234618..1235535 + 918 WP_002294193.1 osmoprotectant ABC transporter substrate-binding protein -
E3O43_RS06130 (E3O43_06480) 1235532..1236203 + 672 WP_002319469.1 ABC transporter permease -
E3O43_RS06135 (E3O43_06485) 1236745..1237233 - 489 WP_002294196.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
E3O43_RS06140 (E3O43_06490) 1237434..1237700 - 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
E3O43_RS06145 (E3O43_06495) 1237700..1237963 - 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3O43_RS06150 1238303..1238428 - 126 WP_002348886.1 hypothetical protein -
E3O43_RS06155 (E3O43_06505) 1238438..1238623 + 186 WP_002294201.1 hypothetical protein -
E3O43_RS06160 (E3O43_06510) 1238765..1240588 - 1824 WP_002294202.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T120733 WP_002294198.1 NZ_CP038163:c1237700-1237434 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T120733 NZ_CP038163:c1237700-1237434 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT120733 WP_002294199.1 NZ_CP038163:c1237963-1237700 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT120733 NZ_CP038163:c1237963-1237700 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References