Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1698604..1699216 Replicon chromosome
Accession NZ_CP038155
Organism Arsenophonus endosymbiont of Aphis craccivora isolate Ash

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag E3U36_RS08655 Protein ID WP_180816264.1
Coordinates 1698827..1699216 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag E3U36_RS08650 Protein ID WP_180816263.1
Coordinates 1698604..1698825 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3U36_RS08625 1694498..1694956 + 459 WP_180816258.1 dUTP diphosphatase -
E3U36_RS08630 1695071..1695670 + 600 WP_180816259.1 nucleoid occlusion factor SlmA -
E3U36_RS08635 1695741..1696406 - 666 WP_180816260.1 orotate phosphoribosyltransferase -
E3U36_RS08640 1696480..1697196 - 717 WP_180816261.1 ribonuclease PH -
E3U36_RS08645 1697315..1698178 + 864 WP_180816262.1 YicC family protein -
E3U36_RS08650 1698604..1698825 + 222 WP_180816263.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
E3U36_RS08655 1698827..1699216 + 390 WP_180816264.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
E3U36_RS08660 1700064..1700987 - 924 WP_180816265.1 IS5 family transposase -
E3U36_RS08665 1701098..1701847 + 750 Protein_1664 LuxR family transcriptional regulator -
E3U36_RS08670 1701818..1702481 - 664 Protein_1665 acyl-homoserine-lactone synthase -
E3U36_RS08675 1702836..1703759 - 924 WP_180816102.1 IS5 family transposase -
E3U36_RS08680 1703753..1703905 + 153 WP_180816266.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1690817..1770724 79907


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14594.44 Da        Isoelectric Point: 4.6873

>T120730 WP_180816264.1 NZ_CP038155:1698827-1699216 [Arsenophonus endosymbiont of Aphis craccivora]
MGQRAQEVIAFHDRILQWLSGVAGMPDPSRAEALIYRVQNRAHYDGVTDIFELAATYWIAIARGHIFNDGNERTAFFVTM
TFLYLNGINIRDNDNTLENLTVEAATGEKTVDQLAQQLRELVNRIEPIG

Download         Length: 390 bp

>T120730 NZ_CP038155:1698827-1699216 [Arsenophonus endosymbiont of Aphis craccivora]
ATGGGTCAGCGCGCACAGGAAGTTATTGCTTTTCATGACCGTATATTGCAATGGCTTTCCGGCGTTGCTGGTATGCCGGA
TCCTAGCAGAGCAGAAGCTCTTATTTACCGGGTACAAAATCGTGCACATTATGACGGTGTTACGGATATTTTTGAGTTGG
CTGCCACTTACTGGATTGCTATCGCCAGAGGTCACATTTTTAATGATGGCAATGAGCGTACCGCGTTTTTTGTGACCATG
ACTTTCCTCTACCTCAACGGTATCAATATCCGAGATAACGACAATACTTTGGAAAATTTAACGGTAGAAGCTGCTACCGG
AGAAAAAACTGTTGATCAGTTAGCGCAGCAGTTACGTGAGTTAGTAAATCGTATCGAGCCAATTGGTTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8130.01 Da        Isoelectric Point: 5.5675

>AT120730 WP_180816263.1 NZ_CP038155:1698604-1698825 [Arsenophonus endosymbiont of Aphis craccivora]
MRTYTSTQARANISEVIDAATHVEPVEITRRDGSSAVVISKAEFEAYQNAKLDAEFDVIIQRHGHTVEALTNR

Download         Length: 222 bp

>AT120730 NZ_CP038155:1698604-1698825 [Arsenophonus endosymbiont of Aphis craccivora]
ATGCGTACATACACTTCCACTCAAGCCCGCGCCAATATCTCAGAAGTGATTGATGCTGCCACTCATGTTGAACCCGTTGA
AATCACCCGCAGGGATGGAAGTTCAGCAGTAGTTATCAGCAAGGCTGAATTCGAGGCATACCAGAACGCTAAGCTGGATG
CGGAGTTTGATGTGATTATACAGCGCCATGGGCATACTGTAGAGGCATTGACAAACCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References