Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 4417376..4417901 Replicon chromosome
Accession NZ_CP038147
Organism Streptomyces sp. S501

Toxin (Protein)


Gene name relE Uniprot ID A0A4P7DII6
Locus tag D7Y56_RS21580 Protein ID WP_015578584.1
Coordinates 4417376..4417639 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3N6F7F2
Locus tag D7Y56_RS21585 Protein ID WP_015578585.1
Coordinates 4417632..4417901 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7Y56_RS21550 4413837..4414592 + 756 WP_134667211.1 restriction endonuclease -
D7Y56_RS21560 4415207..4415599 - 393 WP_015578581.1 hypothetical protein -
D7Y56_RS21565 4415599..4415850 - 252 WP_030123741.1 hypothetical protein -
D7Y56_RS21570 4415956..4416688 - 733 Protein_3947 HEAT repeat domain-containing protein -
D7Y56_RS21575 4416685..4417065 - 381 WP_030124088.1 hypothetical protein -
D7Y56_RS21580 4417376..4417639 - 264 WP_015578584.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D7Y56_RS21585 4417632..4417901 - 270 WP_015578585.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D7Y56_RS21590 4418296..4418982 - 687 WP_041667870.1 hypothetical protein -
D7Y56_RS21595 4418966..4419403 - 438 WP_134666019.1 hypothetical protein -
D7Y56_RS21600 4419424..4421838 - 2415 WP_134666021.1 DUF1906 domain-containing protein -
D7Y56_RS21605 4422201..4422683 + 483 WP_030635603.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-58)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9950.52 Da        Isoelectric Point: 10.4269

>T120726 WP_015578584.1 NZ_CP038147:c4417639-4417376 [Streptomyces sp. S501]
VSEYRAVFRPEAQAELRKIPREKALRILTKLTELESAPLGFATTALVSQPERRRLRVGDYRVVYTIDKGELVVWVVHVGH
RSTVYGT

Download         Length: 264 bp

>T120726 NZ_CP038147:c4417639-4417376 [Streptomyces sp. S501]
GTGAGTGAGTACCGGGCCGTCTTCCGGCCAGAGGCACAGGCCGAGCTCCGGAAGATCCCTCGCGAAAAGGCCCTACGCAT
CCTGACCAAACTGACCGAGCTGGAGAGCGCCCCCCTCGGCTTTGCCACCACCGCGCTCGTGTCACAGCCGGAACGCCGTC
GGCTGCGGGTCGGTGACTACCGCGTCGTCTACACGATCGACAAGGGAGAGCTCGTGGTGTGGGTCGTCCACGTCGGGCAT
CGCTCCACCGTCTACGGCACCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10304.81 Da        Isoelectric Point: 4.7473

>AT120726 WP_015578585.1 NZ_CP038147:c4417901-4417632 [Streptomyces sp. S501]
MTQPLPIESIRDVRAHLAEVVERADRDDMPTVITRRGKQIAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Download         Length: 270 bp

>AT120726 NZ_CP038147:c4417901-4417632 [Streptomyces sp. S501]
ATGACGCAGCCACTGCCCATAGAGTCCATCCGTGACGTACGTGCACACCTGGCCGAGGTCGTGGAGCGCGCCGATCGAGA
TGACATGCCCACCGTGATCACCCGACGGGGCAAGCAGATTGCCGCTGTCGTCTCCATCGAGGTGCTGCGCAAGTACCAGG
AATGGGAAGAGCGCGAGATCAACCGGATCATCGACGAACGCATGGCCAACCCGGCACCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCGGTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7DII6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N6F7F2

References