Detailed information of TA system TA120725

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1993447..1994084
• Replicon: chromosome
• Accession: NZ_CP038147
• Organism: Streptomyces sp. S501

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D7Y56_RS10475
• Protein ID: WP_015577067.1
• Coordinates: 1993447..1993854 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A212SI58
• Locus tag: D7Y56_RS10480
• Protein ID: WP_015577068.1
• Coordinates: 1993851..1994084 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D7Y56_RS10450	1989105..1989941	-	837	WP_030122626.1	DUF4397 domain-containing protein	-
D7Y56_RS10455	1990132..1990392	-	261	WP_051694761.1	hypothetical protein	-
D7Y56_RS10460	1990873..1991229	-	357	WP_134665014.1	MarR family transcriptional regulator	-
D7Y56_RS10465	1991364..1991921	+	558	WP_134665015.1	universal stress protein	-
D7Y56_RS10470	1991918..1992840	+	923	Protein_1800	TerC family protein	-
D7Y56_RS10475	1993447..1993854	-	408	WP_015577067.1	PIN domain nuclease	Toxin
D7Y56_RS10480	1993851..1994084	-	234	WP_015577068.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
D7Y56_RS10500	1995068..1995370	+	303	WP_014156408.1	YtxH domain-containing protein	-
D7Y56_RS10505	1995453..1996898	+	1446	WP_014156407.1	sugar kinase	-
D7Y56_RS10510	1997035..1998768	+	1734	WP_014156406.1	ABC transporter ATP-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1983256..1995370	12114

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-45)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15000.00 Da
• Isoelectric Point: 6.3974

>T120725 WP_015577067.1 NZ_CP038147:c1993854-1993447 [Streptomyces sp. S501]
VITYLLDTSALWHLFRTPGALRPWEGHIAAGVFHICEPTRAEFLFSATSPADRDELAEELDDLCHLAPVPKSAWRWVDTA
QYKLTQRGQHRAAGAIDLLVCATAVHHGHTVLHVDNDFATVGAVLKEVQQRDVRA

Nucleotide

• Length: 408 bp

>T120725 NZ_CP038147:c1993854-1993447 [Streptomyces sp. S501]
GTGATCACATACCTCCTCGACACGTCCGCCCTCTGGCACCTCTTCCGTACGCCGGGGGCACTGCGTCCCTGGGAGGGGCA
CATCGCTGCCGGTGTGTTCCATATCTGCGAGCCCACGAGGGCGGAGTTCCTCTTCTCGGCCACAAGCCCGGCTGATCGGG
ACGAGTTGGCCGAGGAGCTGGATGACCTCTGTCATCTCGCCCCGGTTCCCAAGAGTGCGTGGCGCTGGGTCGACACCGCG
CAGTACAAGCTCACCCAGCGGGGGCAGCATCGTGCCGCCGGAGCCATCGACCTCCTGGTGTGTGCGACGGCGGTCCATCA
CGGTCACACGGTGCTGCACGTGGACAACGACTTCGCCACGGTGGGGGCGGTCCTGAAGGAAGTGCAGCAACGAGACGTAC
GCGCCTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8304.43 Da
• Isoelectric Point: 7.0151

>AT120725 WP_015577068.1 NZ_CP038147:c1994084-1993851 [Streptomyces sp. S501]
MSVTQVDLDDEALAEAMRLMGVSTKKETVNGALRDYVARIKRLEAAEKLAARGERGEFEAAAAAHAAAKQARRAAFE

Nucleotide

• Length: 234 bp

>AT120725 NZ_CP038147:c1994084-1993851 [Streptomyces sp. S501]
ATGTCTGTGACCCAGGTCGATCTCGATGATGAGGCGCTGGCTGAGGCGATGCGGCTCATGGGTGTCTCGACGAAGAAGGA
GACGGTGAACGGGGCCCTACGGGACTATGTGGCGCGCATCAAGCGGCTGGAGGCTGCCGAGAAGCTGGCCGCGAGGGGTG
AGCGGGGCGAGTTCGAGGCTGCGGCTGCGGCGCATGCAGCGGCCAAGCAGGCCCGGCGGGCAGCCTTCGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A212SI58