Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2005489..2006092 Replicon chromosome
Accession NZ_CP038145
Organism Actinobacillus indolicus strain AIFJ1607

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EXH44_RS09900 Protein ID WP_208717139.1
Coordinates 2005489..2005764 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EXH44_RS09905 Protein ID WP_162857341.1
Coordinates 2005757..2006092 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXH44_RS09880 2000609..2001364 - 756 WP_162857338.1 molybdopterin-synthase adenylyltransferase MoeB -
EXH44_RS09885 2001366..2002598 - 1233 WP_162857339.1 molybdopterin molybdotransferase MoeA -
EXH44_RS09890 2002759..2003382 - 624 WP_135673836.1 MarC family protein -
EXH44_RS09895 2003462..2005375 + 1914 WP_162857340.1 ABC transporter ATP-binding protein -
EXH44_RS09900 2005489..2005764 + 276 WP_208717139.1 type II toxin-antitoxin system HicA family toxin Toxin
EXH44_RS09905 2005757..2006092 + 336 WP_162857341.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EXH44_RS09910 2006102..2007076 + 975 WP_162857342.1 o-succinylbenzoate synthase -
EXH44_RS09915 2007113..2007850 - 738 WP_162857343.1 peptidoglycan editing factor PgeF -
EXH44_RS09920 2007854..2008243 - 390 WP_075605421.1 RidA family protein -
EXH44_RS09925 2008379..2009380 + 1002 WP_162857344.1 nucleoid-associated protein YejK -
EXH44_RS09930 2009441..2009788 + 348 WP_162857575.1 outer membrane protein assembly factor BamE -
EXH44_RS09935 2009885..2011003 + 1119 WP_162857345.1 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(28-79)

Antitoxin

Uncharacterised protein family HicB

(56-105)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10455.12 Da        Isoelectric Point: 9.9150

>T120724 WP_208717139.1 NZ_CP038145:2005489-2005764 [Actinobacillus indolicus]
MVSFYIRKKHQKTLVQLYQHPISANIKWSDIEALFLELGATIQEREGSRIAIILFGQVKVFHRPHPNPDTDKGAVVSVRK
WLEENGVVPYA

Download         Length: 276 bp

>T120724 NZ_CP038145:2005489-2005764 [Actinobacillus indolicus]
ATGGTTTCATTTTATATTAGAAAGAAACATCAAAAGACACTCGTTCAGCTTTATCAGCATCCAATTTCAGCAAACATAAA
ATGGTCTGATATTGAAGCACTTTTTCTTGAACTCGGAGCAACAATTCAAGAGAGAGAAGGAAGTCGAATTGCAATTATTT
TGTTTGGTCAAGTTAAAGTATTCCATCGACCACATCCAAATCCAGATACAGATAAAGGGGCTGTTGTGTCGGTAAGAAAA
TGGCTAGAAGAAAATGGGGTTGTTCCGTATGCGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12357.93 Da        Isoelectric Point: 4.8429

>AT120724 WP_162857341.1 NZ_CP038145:2005757-2006092 [Actinobacillus indolicus]
MRNIMEINGHKAVIAYDADIELFRGEFIGLNGGADFYADNVIDLRKEGEKSLQTFLDICQEQGISPYKSYSGRFNVRISS
ELHCAAVTAAAAQNISLNEWINQTIAKSLEK

Download         Length: 336 bp

>AT120724 NZ_CP038145:2005757-2006092 [Actinobacillus indolicus]
ATGCGTAATATAATGGAAATCAATGGGCATAAAGCTGTGATTGCTTATGATGCTGATATCGAACTTTTTCGTGGTGAATT
TATCGGCTTAAATGGTGGTGCGGATTTTTACGCTGATAATGTCATTGATTTACGAAAAGAAGGTGAAAAAAGTTTACAAA
CCTTTTTAGACATTTGCCAAGAGCAAGGGATATCGCCTTATAAATCTTATTCAGGGCGTTTTAATGTCAGAATAAGTTCT
GAATTACATTGTGCCGCAGTTACTGCTGCTGCAGCACAAAATATCAGTTTAAATGAATGGATTAATCAAACGATTGCTAA
ATCGCTTGAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References