120695

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 40685..42038 Replicon plasmid pAsa9-like
Accession NZ_CP038104
Organism Aeromonas salmonicida subsp. salmonicida strain SHY16-3432

Toxin (Protein)


Gene name sanaT Uniprot ID A0A1Z3MNN1
Locus tag E3D14_RS23720 Protein ID WP_005321447.1
Coordinates 41073..42038 (+) Length 322 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A807ZF76
Locus tag E3D14_RS23715 Protein ID WP_042468273.1
Coordinates 40685..41083 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3D14_RS23700 38108..38554 + 447 WP_005322271.1 hypothetical protein -
E3D14_RS23705 38900..39262 - 363 WP_063968043.1 hypothetical protein -
E3D14_RS23710 39302..39748 - 447 WP_063968044.1 DNA repair protein RadC -
E3D14_RS23715 40685..41083 + 399 WP_042468273.1 S-adenosylhomocysteine hydrolase Antitoxin
E3D14_RS23720 41073..42038 + 966 WP_005321447.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
E3D14_RS23725 42362..42514 + 153 WP_005321445.1 type I toxin-antitoxin system Hok family toxin -
E3D14_RS23730 42644..42829 + 186 WP_005321442.1 hypothetical protein -
E3D14_RS23735 43260..44669 + 1410 WP_005321439.1 DUF3696 domain-containing protein -
E3D14_RS23740 44653..45183 + 531 WP_043816360.1 hypothetical protein -
E3D14_RS23745 45187..45888 + 702 WP_005321423.1 RNA ligase family protein -
E3D14_RS23750 46037..46642 + 606 WP_043816358.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..74314 74314


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(43-302)

Antitoxin

Protein of unknown function DUF6088

(7-128)


Sequences

Toxin        


Download         Length: 322 a.a.        Molecular weight: 36512.59 Da        Isoelectric Point: 5.1489

>T120695 WP_005321447.1 NZ_CP038104:41073-42038 [Aeromonas salmonicida subsp. salmonicida]
MQPKDSSIFADVSDYFGIDNPAIAEKDYYVVQLLKLLASHYCQHHTMVFAGGTALAKADVKLQRMSEDVDIKLSVNDSAK
DESRSAMKRHRKAIRDGLIEELNATGVFQVERAEVTCRDEHRYIEMPVRYPQAFSKAPCLRPFIKLELIETDLLAGHNPM
PICSLHNEAMQQEPEVPAFNTVPLISTQAEKVLSMLRRTASVKHDPERLDDESLVRHIYDTYRLQQSTTFDLAELAGLIA
EGMKMDRDRYGPQHPEFAADPIGVMRFGLDVIAGDPLYKDRYEAFVKPMVYGDALTWDEAFRVFEAVARQALDHIEQHEL
I

Download         Length: 966 bp

>T120695 NZ_CP038104:41073-42038 [Aeromonas salmonicida subsp. salmonicida]
ATGCAGCCTAAAGACTCTTCGATTTTCGCCGACGTTTCTGACTACTTCGGGATCGATAACCCTGCGATAGCAGAAAAGGA
CTACTACGTCGTCCAGCTGCTCAAACTGCTTGCAAGTCATTATTGCCAGCACCACACCATGGTGTTTGCAGGCGGGACCG
CATTAGCCAAAGCTGACGTCAAGCTTCAGCGCATGTCTGAAGATGTCGACATCAAGTTATCTGTTAACGATAGTGCTAAA
GATGAATCTCGAAGCGCGATGAAGCGCCATCGCAAAGCCATCCGAGATGGTTTGATTGAAGAGCTCAATGCGACTGGCGT
TTTCCAAGTAGAGAGGGCTGAGGTCACTTGTCGGGATGAGCACAGGTACATTGAAATGCCGGTGAGATACCCGCAGGCCT
TCAGCAAGGCCCCCTGCCTTCGGCCTTTCATCAAGCTCGAACTCATTGAGACTGATCTGCTTGCAGGCCATAACCCCATG
CCCATTTGTTCGCTGCACAATGAAGCGATGCAGCAAGAACCTGAAGTGCCAGCCTTCAACACGGTTCCCCTGATCTCCAC
CCAAGCCGAGAAAGTGTTGTCGATGCTGCGCAGAACAGCCAGCGTCAAGCATGACCCAGAACGATTGGATGATGAGTCGT
TGGTTCGCCACATTTATGACACTTATCGCCTGCAACAAAGTACCACCTTTGATTTGGCCGAACTGGCAGGGCTGATAGCT
GAAGGGATGAAGATGGATCGTGATCGCTATGGTCCCCAACACCCCGAGTTTGCAGCAGATCCTATCGGTGTGATGCGGTT
TGGCCTGGATGTGATTGCTGGTGACCCCCTATACAAAGATCGTTATGAGGCATTCGTGAAGCCGATGGTGTATGGGGATG
CGTTGACTTGGGATGAGGCATTTCGCGTGTTCGAGGCTGTTGCGCGCCAGGCTCTAGATCACATTGAGCAACACGAACTT
ATTTAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14761.36 Da        Isoelectric Point: 11.0142

>AT120695 WP_042468273.1 NZ_CP038104:40685-41083 [Aeromonas salmonicida subsp. salmonicida]
MTIADRVEARIKRSKRDVFLREDFDDLGGYDQIGRALRQMCEKGLLLKVGYGVYAKARRNRINSRLMIASPGGPDAVLIA
TLDRLKVPYELKGLTAAYAAGKSTQVPAFMEVKPKKRFSRKLKIGSRVFNAA

Download         Length: 399 bp

>AT120695 NZ_CP038104:40685-41083 [Aeromonas salmonicida subsp. salmonicida]
ATGACCATTGCAGACCGTGTTGAAGCACGAATCAAACGATCTAAGCGAGATGTGTTTCTCCGTGAGGATTTCGATGACTT
GGGCGGTTATGACCAAATAGGCAGAGCCTTACGCCAGATGTGTGAAAAGGGTCTGCTTCTGAAGGTCGGCTACGGCGTGT
ATGCAAAGGCACGGCGTAACCGGATCAATAGTCGCTTGATGATCGCCTCCCCTGGAGGCCCAGACGCCGTACTCATTGCT
ACGCTTGACCGCCTGAAGGTGCCTTACGAACTGAAGGGCCTGACCGCAGCTTATGCCGCGGGGAAATCCACTCAGGTTCC
CGCCTTTATGGAAGTTAAGCCTAAAAAGCGTTTTTCCAGAAAGCTGAAAATAGGAAGCCGAGTGTTCAATGCAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z3MNN1

Antitoxin

Source ID Structure
AlphaFold DB A0A807ZF76

References