Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4446991..4447562 Replicon chromosome
Accession NZ_CP038101
Organism Saccharomonospora xinjiangensis strain 31sw

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EYD13_RS20750 Protein ID WP_209020358.1
Coordinates 4447209..4447562 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EYD13_RS20745 Protein ID WP_134718029.1
Coordinates 4446991..4447212 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYD13_RS20725 4443933..4444418 + 486 WP_134718021.1 MarR family transcriptional regulator -
EYD13_RS20730 4444402..4445085 - 684 WP_134718023.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
EYD13_RS20735 4445148..4446086 + 939 WP_134718025.1 ATP-binding cassette domain-containing protein -
EYD13_RS20740 4446083..4446949 + 867 WP_134718027.1 ABC transporter permease -
EYD13_RS20745 4446991..4447212 + 222 WP_134718029.1 ribbon-helix-helix domain-containing protein Antitoxin
EYD13_RS20750 4447209..4447562 + 354 WP_209020358.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EYD13_RS20755 4447698..4448711 + 1014 WP_209020249.1 homocysteine S-methyltransferase -
EYD13_RS20760 4448874..4449896 - 1023 WP_134718031.1 GNAT family N-acetyltransferase -
EYD13_RS20765 4449893..4450894 - 1002 WP_134718033.1 GNAT family N-acetyltransferase -
EYD13_RS20770 4450891..4452033 - 1143 WP_134718034.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 12681.67 Da        Isoelectric Point: 11.7517

>T120693 WP_209020358.1 NZ_CP038101:4447209-4447562 [Saccharomonospora xinjiangensis]
MMRRGDIYLADLEPVRGSESDKRRPVVVVSNDGANATAARLGRGVVTVVPVTSNVTRVFPFQVRLPAKETGLAKDSKAQA
EQVRSIAVERLGRRIGRLTPPLSRALDDALRLHLGLG

Download         Length: 354 bp

>T120693 NZ_CP038101:4447209-4447562 [Saccharomonospora xinjiangensis]
CTGATGCGCAGGGGCGACATCTACCTCGCCGATCTGGAACCGGTGCGCGGCTCGGAGAGCGACAAACGGCGGCCCGTGGT
CGTCGTCAGCAACGACGGCGCCAACGCCACGGCTGCCCGGCTCGGCCGCGGTGTCGTGACCGTCGTGCCGGTGACCTCCA
ACGTGACCAGGGTGTTTCCCTTCCAGGTTCGGCTGCCCGCGAAGGAGACAGGGCTGGCGAAAGACTCGAAGGCGCAGGCC
GAGCAGGTGCGCTCCATTGCCGTGGAACGGCTCGGCAGGCGGATCGGCCGCCTCACCCCACCGCTGAGCCGGGCTCTCGA
CGACGCGCTGCGGCTGCACCTCGGCCTCGGGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8241.03 Da        Isoelectric Point: 4.6211

>AT120693 WP_134718029.1 NZ_CP038101:4446991-4447212 [Saccharomonospora xinjiangensis]
MKVSVSLPSEDVEFLDEYARQHRIGSRSAALHHAVELLKAARLGDAYAEAWQEWESSGEAEQWEQTAADGLRR

Download         Length: 222 bp

>AT120693 NZ_CP038101:4446991-4447212 [Saccharomonospora xinjiangensis]
ATGAAGGTGAGCGTGAGTCTGCCGAGCGAGGACGTCGAGTTCCTCGACGAGTACGCGCGCCAACACCGCATCGGCTCGCG
CTCCGCAGCCCTGCACCACGCCGTCGAACTGCTGAAGGCCGCCCGCCTCGGCGACGCCTACGCCGAGGCGTGGCAGGAAT
GGGAGTCCTCGGGCGAGGCCGAGCAGTGGGAGCAGACCGCCGCGGACGGCCTGCGACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References