Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3937941..3938595 Replicon chromosome
Accession NZ_CP038033
Organism Nitrosococcus wardiae strain D1FHS

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E3U44_RS18680 Protein ID WP_134359922.1
Coordinates 3937941..3938360 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E3U44_RS18685 Protein ID WP_134359923.1
Coordinates 3938362..3938595 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3U44_RS19470 3933012..3933953 - 942 WP_206054849.1 hypothetical protein -
E3U44_RS18650 3934060..3934326 + 267 WP_134359538.1 transposase -
E3U44_RS18655 3934403..3934906 + 504 WP_134359539.1 IS630 family transposase -
E3U44_RS18660 3934912..3935460 + 549 WP_134356954.1 IS630 family transposase -
E3U44_RS18665 3935396..3935782 - 387 WP_166805131.1 FRG domain-containing protein -
E3U44_RS18670 3936578..3936811 - 234 WP_134359541.1 hypothetical protein -
E3U44_RS18675 3937155..3937601 - 447 WP_134359542.1 hypothetical protein -
E3U44_RS18680 3937941..3938360 - 420 WP_134359922.1 type II toxin-antitoxin system VapC family toxin Toxin
E3U44_RS18685 3938362..3938595 - 234 WP_134359923.1 antitoxin Antitoxin
E3U44_RS18690 3938895..3939437 - 543 WP_134359543.1 hypothetical protein -
E3U44_RS18695 3939553..3939999 + 447 WP_134357487.1 helix-turn-helix domain-containing protein -
E3U44_RS18700 3940023..3940502 + 480 WP_166805020.1 IS630 family transposase -
E3U44_RS18705 3940581..3942422 + 1842 Protein_3692 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(6-45)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15854.28 Da        Isoelectric Point: 10.1810

>T120689 WP_134359922.1 NZ_CP038033:c3938360-3937941 [Nitrosococcus wardiae]
MRYLLDTDICIYIINRQPAEVRDRFAHLAPGSVGISVVTYHELYFGALQSRHTEKNLQALQQLTQRVPALPWSTEAAIQT
ARLRLALKRRGQPIGSWDMQIAGHALALNLELVTNNIREFGRIEHLRVETWVKPNAKTS

Download         Length: 420 bp

>T120689 NZ_CP038033:c3938360-3937941 [Nitrosococcus wardiae]
TTGCGCTATTTGTTGGACACAGATATCTGCATTTACATCATCAATCGACAGCCTGCCGAGGTGCGTGATCGGTTTGCGCA
TCTCGCGCCAGGCAGCGTCGGCATCTCGGTCGTTACTTACCACGAACTCTATTTTGGCGCTCTCCAAAGCCGTCATACTG
AGAAAAACCTTCAAGCATTACAGCAACTTACCCAGCGAGTGCCGGCTTTGCCCTGGTCTACTGAAGCGGCGATACAAACG
GCACGGCTGCGCTTGGCGCTCAAACGCCGCGGTCAACCCATCGGCTCCTGGGATATGCAAATTGCCGGCCATGCACTGGC
GCTGAACCTTGAGTTGGTCACTAACAACATACGCGAATTCGGTCGTATCGAGCATTTACGGGTAGAAACCTGGGTGAAAC
CCAACGCAAAAACCTCTTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8743.93 Da        Isoelectric Point: 4.3351

>AT120689 WP_134359923.1 NZ_CP038033:c3938595-3938362 [Nitrosococcus wardiae]
MLTRVFKNGNSLAVRLPAEFALPEGEVEIVRHGNELIIRPVEKNLLGAWEALCSFSDDFMSEGREQPPLQERETVFD

Download         Length: 234 bp

>AT120689 NZ_CP038033:c3938595-3938362 [Nitrosococcus wardiae]
ATGCTGACTCGGGTTTTTAAAAACGGCAATTCCCTGGCGGTTCGTTTGCCGGCGGAGTTCGCTTTACCAGAAGGCGAAGT
CGAAATCGTTCGCCATGGCAATGAATTAATTATCCGTCCCGTCGAAAAGAATTTACTCGGCGCGTGGGAAGCCTTGTGCA
GTTTCTCGGACGATTTCATGAGCGAGGGCCGGGAACAACCACCGTTACAAGAGCGGGAGACTGTCTTTGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References