Detailed information of TA system TA120688

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 3871562..3871973
• Replicon: chromosome
• Accession: NZ_CP038033
• Organism: Nitrosococcus wardiae strain D1FHS

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: E3U44_RS18340
• Protein ID: WP_134359489.1
• Coordinates: 3871562..3871747 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: E3U44_RS18345
• Protein ID: WP_134359490.1
• Coordinates: 3871758..3871973 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3U44_RS18315	3866884..3867816	+	933	WP_134359484.1	J domain-containing protein	-
E3U44_RS18320	3867935..3868519	+	585	WP_134359485.1	hypothetical protein	-
E3U44_RS18325	3868509..3869186	+	678	WP_134359486.1	hypothetical protein	-
E3U44_RS18330	3870785..3871078	+	294	WP_134359487.1	BrnT family toxin	-
E3U44_RS18335	3871068..3871352	+	285	WP_134359488.1	hypothetical protein	-
E3U44_RS18340	3871562..3871747	+	186	WP_134359489.1	type II toxin-antitoxin system HicA family toxin	Toxin
E3U44_RS18345	3871758..3871973	+	216	WP_134359490.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
E3U44_RS18350	3872236..3873123	-	888	WP_134357379.1	IS982 family transposase	-
E3U44_RS18355	3873712..3873939	+	228	WP_134359491.1	carbon storage regulator	-
E3U44_RS18360	3874046..3874771	+	726	WP_134359492.1	DCL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-62)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6682.89 Da
• Isoelectric Point: 10.4763

>T120688 WP_134359489.1 NZ_CP038033:3871562-3871747 [Nitrosococcus wardiae]
MKVEEVIPMLEYEGGYLVQVRGSHRQFKHPKKPGKVTVAGKPSVDVPPGTLNTILKQAGLK

Nucleotide

• Length: 186 bp

>T120688 NZ_CP038033:3871562-3871747 [Nitrosococcus wardiae]
ATGAAAGTAGAGGAGGTCATTCCAATGCTTGAGTACGAGGGTGGGTATCTTGTTCAGGTACGAGGTAGCCACCGCCAGTT
CAAGCATCCCAAAAAGCCCGGAAAAGTCACCGTGGCCGGCAAACCCAGCGTGGATGTTCCGCCGGGGACGCTCAACACTA
TCCTGAAGCAGGCGGGTCTAAAGTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7753.74 Da
• Isoelectric Point: 4.1438

>AT120688 WP_134359490.1 NZ_CP038033:3871758-3871973 [Nitrosococcus wardiae]
MRDRVVIERGPKSWGAYVPDLPGCAAVGETKEEVLELIQGAIELHLEELRADGEPLPEPHSEASYVEVSAI

Nucleotide

• Length: 216 bp

>AT120688 NZ_CP038033:3871758-3871973 [Nitrosococcus wardiae]
ATGAGAGATAGGGTCGTGATTGAGCGAGGCCCCAAGAGTTGGGGCGCGTATGTGCCCGATCTTCCCGGCTGTGCCGCTGT
AGGGGAGACGAAAGAGGAGGTTTTAGAGCTTATCCAAGGGGCCATTGAACTTCACTTGGAAGAGCTTAGAGCGGACGGCG
AACCCCTCCCCGAGCCCCATTCGGAGGCGAGCTATGTGGAGGTGTCCGCTATCTAG