Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pasABC/RelE-HTH |
| Location | 2028598..2029078 | Replicon | chromosome |
| Accession | NZ_CP038033 | ||
| Organism | Nitrosococcus wardiae strain D1FHS | ||
Toxin (Protein)
| Gene name | pasB | Uniprot ID | - |
| Locus tag | E3U44_RS09845 | Protein ID | WP_134357965.1 |
| Coordinates | 2028806..2029078 (+) | Length | 91 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | D5BWF4 |
| Locus tag | E3U44_RS09840 | Protein ID | WP_013033471.1 |
| Coordinates | 2028598..2028822 (+) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3U44_RS09780 | 2024678..2024938 | - | 261 | WP_134359756.1 | BrnT family toxin | - |
| E3U44_RS09785 | 2024992..2025270 | + | 279 | WP_134357958.1 | BrnA antitoxin family protein | - |
| E3U44_RS09790 | 2025527..2025886 | + | 360 | WP_206054750.1 | hypothetical protein | - |
| E3U44_RS09795 | 2025886..2026134 | + | 249 | WP_134357959.1 | hypothetical protein | - |
| E3U44_RS09800 | 2026275..2026523 | - | 249 | WP_134357960.1 | DUF2442 domain-containing protein | - |
| E3U44_RS09805 | 2026531..2026779 | - | 249 | WP_134357961.1 | DUF4160 domain-containing protein | - |
| E3U44_RS09810 | 2026831..2027109 | - | 279 | WP_134357962.1 | HigA family addiction module antidote protein | - |
| E3U44_RS09815 | 2027173..2027322 | - | 150 | WP_206054978.1 | CopG family transcriptional regulator | - |
| E3U44_RS09820 | 2027462..2027620 | - | 159 | WP_134359758.1 | BrnT family toxin | - |
| E3U44_RS09825 | 2027647..2027829 | + | 183 | WP_134357964.1 | hypothetical protein | - |
| E3U44_RS09830 | 2027867..2028160 | - | 294 | WP_206054979.1 | helix-turn-helix domain-containing protein | - |
| E3U44_RS09835 | 2028164..2028457 | - | 294 | Protein_1944 | transcriptional regulator | - |
| E3U44_RS09840 | 2028598..2028822 | + | 225 | WP_013033471.1 | TraY domain-containing protein | Antitoxin |
| E3U44_RS09845 | 2028806..2029078 | + | 273 | WP_134357965.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| E3U44_RS09850 | 2029233..2029454 | - | 222 | WP_134357966.1 | pilus assembly protein HicB | - |
| E3U44_RS09855 | 2029451..2029654 | - | 204 | WP_134357967.1 | type II toxin-antitoxin system HicA family toxin | - |
| E3U44_RS09860 | 2029704..2029787 | - | 84 | WP_134359762.1 | hypothetical protein | - |
| E3U44_RS09865 | 2029824..2030111 | - | 288 | WP_134357968.1 | helix-turn-helix domain-containing protein | - |
| E3U44_RS09870 | 2030967..2031227 | - | 261 | WP_134357969.1 | helix-turn-helix domain-containing protein | - |
| E3U44_RS09875 | 2031229..2031510 | - | 282 | WP_134357970.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| E3U44_RS09880 | 2031477..2032349 | - | 873 | WP_134357971.1 | hypothetical protein | - |
| E3U44_RS09885 | 2032833..2033699 | - | 867 | WP_134357972.1 | PD-(D/E)XK nuclease family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10465.22 Da Isoelectric Point: 9.9216
>T120685 WP_134357965.1 NZ_CP038033:2028806-2029078 [Nitrosococcus wardiae]
MAWRIELSGLAQKNLHGLDKQIAERILRFLNDRIAKLDDPRSIGDPLKGAKLGEFWKYRVGDYCIIADIQDSELLILVVR
IGNRREVYKR
MAWRIELSGLAQKNLHGLDKQIAERILRFLNDRIAKLDDPRSIGDPLKGAKLGEFWKYRVGDYCIIADIQDSELLILVVR
IGNRREVYKR
Download Length: 273 bp
>T120685 NZ_CP038033:2028806-2029078 [Nitrosococcus wardiae]
ATGGCCTGGCGGATTGAGTTGTCGGGACTGGCGCAAAAAAACCTGCACGGACTGGATAAACAGATAGCGGAGCGAATCCT
ACGCTTTTTGAATGATCGGATCGCCAAGCTGGACGACCCGCGCAGTATCGGCGATCCCCTCAAGGGCGCGAAGCTGGGCG
AGTTCTGGAAATACCGTGTCGGTGATTATTGCATTATCGCCGACATTCAGGATAGCGAATTGCTGATTCTGGTGGTGCGG
ATTGGCAACCGCCGGGAGGTTTACAAGCGGTGA
ATGGCCTGGCGGATTGAGTTGTCGGGACTGGCGCAAAAAAACCTGCACGGACTGGATAAACAGATAGCGGAGCGAATCCT
ACGCTTTTTGAATGATCGGATCGCCAAGCTGGACGACCCGCGCAGTATCGGCGATCCCCTCAAGGGCGCGAAGCTGGGCG
AGTTCTGGAAATACCGTGTCGGTGATTATTGCATTATCGCCGACATTCAGGATAGCGAATTGCTGATTCTGGTGGTGCGG
ATTGGCAACCGCCGGGAGGTTTACAAGCGGTGA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8467.70 Da Isoelectric Point: 4.2821
>AT120685 WP_013033471.1 NZ_CP038033:2028598-2028822 [Nitrosococcus wardiae]
MLAIRLPKEIEERLEALAAATGRTKTFYARQAILEYIDDLEDVYLAERELEEVRAGRSIPVPLEDVMKQYGLAD
MLAIRLPKEIEERLEALAAATGRTKTFYARQAILEYIDDLEDVYLAERELEEVRAGRSIPVPLEDVMKQYGLAD
Download Length: 225 bp
>AT120685 NZ_CP038033:2028598-2028822 [Nitrosococcus wardiae]
ATGTTGGCTATCCGACTCCCCAAGGAGATAGAGGAACGTCTGGAAGCGTTGGCCGCTGCTACCGGGCGCACCAAAACCTT
TTACGCCCGCCAAGCCATTCTGGAGTACATTGACGATCTGGAAGACGTGTACTTGGCCGAGCGTGAGCTAGAAGAAGTTC
GTGCGGGTCGCAGCATCCCCGTGCCTCTGGAAGACGTCATGAAGCAATATGGCCTGGCGGATTGA
ATGTTGGCTATCCGACTCCCCAAGGAGATAGAGGAACGTCTGGAAGCGTTGGCCGCTGCTACCGGGCGCACCAAAACCTT
TTACGCCCGCCAAGCCATTCTGGAGTACATTGACGATCTGGAAGACGTGTACTTGGCCGAGCGTGAGCTAGAAGAAGTTC
GTGCGGGTCGCAGCATCCCCGTGCCTCTGGAAGACGTCATGAAGCAATATGGCCTGGCGGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|