Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 227798..228411 Replicon chromosome
Accession NZ_CP038033
Organism Nitrosococcus wardiae strain D1FHS

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E3U44_RS01100 Protein ID WP_134356272.1
Coordinates 228022..228411 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E3U44_RS01095 Protein ID WP_134356271.1
Coordinates 227798..228022 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3U44_RS01070 222995..223378 + 384 WP_134356266.1 hypothetical protein -
E3U44_RS01075 223921..224850 + 930 WP_134356267.1 OmpA family protein -
E3U44_RS01080 225023..226378 + 1356 WP_134356268.1 MATE family efflux transporter -
E3U44_RS01085 226437..226733 - 297 WP_166804978.1 PepSY domain-containing protein -
E3U44_RS01090 227209..227637 - 429 WP_134356270.1 DedA family protein -
E3U44_RS01095 227798..228022 + 225 WP_134356271.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3U44_RS01100 228022..228411 + 390 WP_134356272.1 type II toxin-antitoxin system VapC family toxin Toxin
E3U44_RS01105 228489..228752 - 264 WP_134356273.1 type II toxin-antitoxin system ParD family antitoxin -
E3U44_RS01110 229061..229330 + 270 WP_134356274.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
E3U44_RS01115 229327..229728 + 402 WP_134356275.1 type II toxin-antitoxin system VapC family toxin -
E3U44_RS01120 230205..231296 + 1092 WP_166804979.1 glycosyltransferase family 4 protein -
E3U44_RS01125 231302..233230 + 1929 WP_134356277.1 asparagine synthase (glutamine-hydrolyzing) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-43)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15080.57 Da        Isoelectric Point: 6.2202

>T120680 WP_134356272.1 NZ_CP038033:228022-228411 [Nitrosococcus wardiae]
VRTLLDTHVFLWLLTEDPRLSPTARRLFLDEENQLFLSMASVWEIAIKTSLGRLEFMEPIEDLLPRELRLNGIHLLPIEI
GHALKLARLPFHHRDPFDRLLVAQSLAENLPLLSADNHLDAYPIKRFWQ

Download         Length: 390 bp

>T120680 NZ_CP038033:228022-228411 [Nitrosococcus wardiae]
GTGCGAACTCTGCTAGATACCCATGTCTTTTTATGGCTCCTGACGGAAGATCCCAGACTTTCACCAACCGCACGCCGCCT
CTTTCTGGATGAAGAAAACCAACTTTTTCTGAGTATGGCTAGCGTCTGGGAAATAGCAATCAAAACCAGCCTAGGGCGTC
TAGAGTTCATGGAGCCCATTGAAGATCTCTTGCCCCGCGAACTGAGATTAAATGGAATTCACCTGCTACCCATTGAAATA
GGGCATGCATTGAAGTTAGCACGGCTTCCCTTTCACCACCGAGACCCCTTCGACAGGCTGCTGGTTGCGCAAAGCCTAGC
CGAAAACCTGCCACTCCTAAGCGCCGATAATCACTTAGATGCTTACCCTATCAAGCGGTTCTGGCAATAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8586.02 Da        Isoelectric Point: 6.7261

>AT120680 WP_134356271.1 NZ_CP038033:227798-228022 [Nitrosococcus wardiae]
MIQVNIHEAKTHLSKLLQKVLEGEEVVIAKDNQPIAKLVLFEEQKPKRRLGRARGLIRIHPDFDAPIEDLEDYM

Download         Length: 225 bp

>AT120680 NZ_CP038033:227798-228022 [Nitrosococcus wardiae]
ATGATTCAAGTTAACATACACGAAGCCAAAACCCATCTTTCAAAGTTACTCCAAAAGGTCCTGGAGGGGGAAGAAGTGGT
CATCGCCAAAGACAATCAGCCTATCGCCAAGCTCGTCTTGTTCGAGGAACAAAAGCCCAAACGCCGCCTTGGAAGGGCGC
GGGGACTCATTCGCATCCATCCTGATTTCGATGCCCCCATTGAGGATCTCGAGGATTATATGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References