120678

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4262943..4263508 Replicon chromosome
Accession NZ_CP038030
Organism Rhodococcus ruber strain R1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E2561_RS19135 Protein ID WP_124258608.1
Coordinates 4262943..4263299 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag E2561_RS19140 Protein ID WP_124258630.1
Coordinates 4263296..4263508 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E2561_RS19110 4259152..4259649 - 498 WP_124258612.1 hypothetical protein -
E2561_RS19115 4260013..4261071 - 1059 WP_124258611.1 beta-mannosidase -
E2561_RS19120 4261258..4261506 + 249 WP_124258610.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
E2561_RS19125 4261503..4261883 + 381 WP_043804893.1 type II toxin-antitoxin system VapC family toxin -
E2561_RS19130 4262041..4262880 + 840 WP_124258609.1 hypothetical protein -
E2561_RS19135 4262943..4263299 - 357 WP_124258608.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E2561_RS19140 4263296..4263508 - 213 WP_124258630.1 ribbon-helix-helix protein, CopG family Antitoxin
E2561_RS19145 4263720..4264301 + 582 WP_140188856.1 GNAT family N-acetyltransferase -
E2561_RS19150 4264309..4264704 - 396 Protein_3786 hypothetical protein -
E2561_RS19155 4264828..4266111 + 1284 WP_140188857.1 competence/damage-inducible protein A -
E2561_RS19160 4266556..4267467 + 912 WP_140189163.1 formylglycine-generating enzyme family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12839.54 Da        Isoelectric Point: 7.3227

>T120678 WP_124258608.1 NZ_CP038030:c4263299-4262943 [Rhodococcus ruber]
MIRRAQIHWVDPDPAQGSEAAERRPAVVVSNDRANATAENLGRGVVTVVPLTTNTSHVFPFQVLVEPDESGLTRAAKAQA
EQVRSVSVRRLDTEPVGKLGARTLAALEEALRLHLDLR

Download         Length: 357 bp

>T120678 NZ_CP038030:c4263299-4262943 [Rhodococcus ruber]
ATGATCCGCCGAGCGCAGATCCACTGGGTCGATCCGGACCCTGCGCAGGGTAGCGAAGCGGCCGAGCGCCGGCCGGCAGT
GGTCGTGAGCAACGACCGCGCCAACGCGACCGCCGAGAATCTGGGCAGAGGAGTGGTCACCGTCGTTCCTCTGACCACCA
ACACCTCACACGTCTTTCCGTTCCAGGTACTCGTGGAACCCGACGAGTCAGGGCTGACCAGAGCAGCGAAAGCTCAGGCA
GAACAGGTACGTTCGGTGTCCGTGCGTCGCCTGGACACCGAACCTGTCGGAAAGCTCGGGGCGAGAACTCTCGCAGCGCT
CGAGGAAGCGCTGCGGCTACATCTCGATTTGCGTTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7688.48 Da        Isoelectric Point: 4.4055

>AT120678 WP_124258630.1 NZ_CP038030:c4263508-4263296 [Rhodococcus ruber]
MTVKFTISLPDEDAHVLDEYIRDHGLRGRSAGVRAAVRLLAAAGLERDYATAFAEVDTEHAWDVTTADTE

Download         Length: 213 bp

>AT120678 NZ_CP038030:c4263508-4263296 [Rhodococcus ruber]
CTGACCGTCAAGTTCACGATCAGTCTCCCGGACGAGGATGCCCACGTCCTCGACGAGTACATCCGGGATCATGGGCTCCG
CGGCCGGTCGGCGGGAGTCCGGGCCGCTGTCCGCCTGCTCGCGGCAGCCGGACTCGAACGGGACTACGCCACGGCCTTTG
CCGAGGTCGACACAGAGCACGCGTGGGATGTCACCACGGCCGACACCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References