120675

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 567872..568789 Replicon chromosome
Accession NZ_CP038028
Organism Bacillus amyloliquefaciens strain FS1092

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag E3U39_RS02400 Protein ID WP_007407256.1
Coordinates 567872..568618 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag E3U39_RS02405 Protein ID WP_003154807.1
Coordinates 568619..568789 (+) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3U39_RS02380 563265..564215 - 951 WP_031378808.1 ring-cleaving dioxygenase -
E3U39_RS02385 564538..565854 + 1317 WP_007610842.1 amino acid permease -
E3U39_RS02390 566140..566757 + 618 WP_003154804.1 DUF47 domain-containing protein -
E3U39_RS02395 566770..567768 + 999 WP_003154805.1 inorganic phosphate transporter -
E3U39_RS02400 567872..568618 + 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
E3U39_RS02405 568619..568789 + 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
E3U39_RS02410 569047..569925 - 879 WP_007407257.1 N-acetylmuramoyl-L-alanine amidase -
E3U39_RS02415 569939..570202 - 264 WP_003154813.1 phage holin -
E3U39_RS02420 570216..570479 - 264 WP_003154815.1 hemolysin XhlA family protein -
E3U39_RS02425 570531..571292 - 762 WP_053573491.1 hypothetical protein -
E3U39_RS02430 571349..571546 - 198 WP_012117366.1 XkdX family protein -
E3U39_RS02435 571551..571976 - 426 WP_053573490.1 hypothetical protein -
E3U39_RS02440 571989..573578 - 1590 WP_053573489.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-239)

Antitoxin

(1-56)


Sequences


Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T120675 WP_007407256.1 NZ_CP038028:567872-568618 [Bacillus amyloliquefaciens]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

>T120675 NZ_CP038028:567872-568618 [Bacillus amyloliquefaciens]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT120675 WP_003154807.1 NZ_CP038028:568619-568789 [Bacillus amyloliquefaciens]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp

>AT120675 NZ_CP038028:568619-568789 [Bacillus amyloliquefaciens]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB I2HQ15


Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References