Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 7102..7679 Replicon plasmid pAR2
Accession NZ_CP038024
Organism Acinetobacter radioresistens strain DD78

Toxin (Protein)


Gene name hicA Uniprot ID N8ZPI0
Locus tag E3H47_RS14570 Protein ID WP_004812233.1
Coordinates 7431..7679 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A062BK26
Locus tag E3H47_RS14565 Protein ID WP_005404859.1
Coordinates 7102..7434 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3H47_RS14540 2624..3943 - 1320 WP_138001021.1 GHKL domain-containing protein -
E3H47_RS14545 3949..4620 - 672 WP_005246441.1 response regulator transcription factor -
E3H47_RS14550 4622..6298 - 1677 WP_000916208.1 phosphoethanolamine--lipid A transferase -
E3H47_RS14560 6668..6916 - 249 Protein_7 rod shape-determining protein -
E3H47_RS14565 7102..7434 - 333 WP_005404859.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E3H47_RS14570 7431..7679 - 249 WP_004812233.1 type II toxin-antitoxin system HicA family toxin Toxin
E3H47_RS14580 8340..8906 - 567 WP_000678311.1 recombinase family protein -
E3H47_RS14585 9456..10538 + 1083 WP_138001022.1 hypothetical protein -
E3H47_RS14590 10959..11756 - 798 WP_138001023.1 abortive infection family protein -
E3H47_RS14595 12024..12419 - 396 WP_138001044.1 rhodanese-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..69207 69207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-78)

Antitoxin

Uncharacterised protein family HicB

(54-101)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9436.02 Da        Isoelectric Point: 10.1337

>T120671 WP_004812233.1 NZ_CP038024:c7679-7431 [Acinetobacter radioresistens]
MGKTEKLLEKFGNSKNTFPYKDLVVLLSQLGYEKFEMAGSRVRFFNEKTEHMILLHRPHPENEIKGGALKAVKQALKQEG
FL

Download         Length: 249 bp

>T120671 NZ_CP038024:c7679-7431 [Acinetobacter radioresistens]
ATGGGTAAAACGGAAAAGTTATTGGAAAAATTTGGAAATTCAAAAAATACGTTTCCATATAAAGATTTAGTCGTTTTACT
GAGCCAGCTCGGCTATGAAAAATTTGAAATGGCAGGCTCTCGTGTTCGGTTTTTTAATGAAAAAACTGAACATATGATTT
TACTGCATAGACCACACCCTGAAAATGAAATCAAAGGTGGGGCATTGAAAGCTGTAAAACAGGCACTCAAGCAGGAGGGA
TTTTTATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12239.00 Da        Isoelectric Point: 4.9061

>AT120671 WP_005404859.1 NZ_CP038024:c7434-7102 [Acinetobacter radioresistens]
MSYLKYKGYLGTIEPDLETGELFGKLAFIRDLITYEAETLKALEKAFQESVDGYLESCAELGKSPDQPFKGTFNVRISPE
LHRKAVLASSNSLNAFVSEAIQEKLMRLGA

Download         Length: 333 bp

>AT120671 NZ_CP038024:c7434-7102 [Acinetobacter radioresistens]
ATGAGCTATTTAAAGTACAAAGGTTATCTCGGAACAATTGAGCCTGATCTTGAAACAGGTGAGTTATTTGGAAAACTTGC
TTTTATTCGTGATCTTATTACCTATGAAGCGGAAACTTTAAAAGCCCTTGAGAAAGCTTTTCAGGAATCTGTAGACGGCT
ATTTAGAATCATGTGCTGAACTAGGAAAATCTCCTGATCAACCATTCAAAGGCACTTTTAATGTCCGTATTAGCCCTGAA
TTGCACCGTAAGGCGGTTTTAGCATCAAGTAATTCTCTAAATGCCTTTGTCAGTGAGGCGATTCAAGAAAAGTTAATGCG
TTTAGGTGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N8ZPI0

Antitoxin

Source ID Structure
AlphaFold DB A0A062BK26

References