Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 76697..77225 Replicon plasmid pAR1
Accession NZ_CP038023
Organism Acinetobacter radioresistens strain DD78

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag E3H47_RS14445 Protein ID WP_000221358.1
Coordinates 76697..76990 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9NWT9
Locus tag E3H47_RS14450 Protein ID WP_000246755.1
Coordinates 76980..77225 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3H47_RS14415 71794..73074 + 1281 WP_138001017.1 cation transporter -
E3H47_RS14420 73086..73346 + 261 WP_004665962.1 ferrous iron transport protein A -
E3H47_RS14425 73336..75165 + 1830 WP_130908662.1 ferrous iron transporter B -
E3H47_RS14440 76239..76568 + 330 WP_004733205.1 four-helix bundle copper-binding protein -
E3H47_RS14445 76697..76990 - 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E3H47_RS14450 76980..77225 - 246 WP_000246755.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
E3H47_RS14455 77384..77812 + 429 WP_000877730.1 hypothetical protein -
E3H47_RS14460 78037..78603 - 567 WP_004282172.1 recombinase family protein -
E3H47_RS14465 78919..79347 + 429 WP_138001018.1 arsenate reductase (glutaredoxin) -
E3H47_RS14470 79392..79715 + 324 WP_138001019.1 metalloregulator ArsR/SmtB family transcription factor -
E3H47_RS14475 79720..80193 + 474 WP_031380725.1 arsenate reductase ArsC -
E3H47_RS14480 80199..81239 + 1041 WP_004644740.1 ACR3 family arsenite efflux transporter -
E3H47_RS14485 81244..81948 + 705 WP_004644739.1 arsenical resistance protein ArsH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..88584 88584


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T120670 WP_000221358.1 NZ_CP038023:c76990-76697 [Acinetobacter radioresistens]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T120670 NZ_CP038023:c76990-76697 [Acinetobacter radioresistens]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
AAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGCGATCTTGCAGGTTGCTATAAAA
TCAAATTATTAAAAGCTGGTGTCCGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCCTGCTCATTACCGTCGGA
AAACGAGCTGATAGCATAGTTTATGACGAAGCGAAAAAGCGAATTAAAGACTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9249.64 Da        Isoelectric Point: 4.3142

>AT120670 WP_000246755.1 NZ_CP038023:c77225-76980 [Acinetobacter radioresistens]
MATVNFRIDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT120670 NZ_CP038023:c77225-76980 [Acinetobacter radioresistens]
ATGGCTACTGTTAACTTCAGGATCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTGCACC
TACGGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCTGTCAAAAAAGCTTTGCTTTCGGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAGCGCATTAATGATCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB A0A6A1RJ80

References