Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2205907..2206421 Replicon chromosome
Accession NZ_CP038021
Organism Staphylococcus aureus strain 04-002

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag E3I93_RS11375 Protein ID WP_000581791.1
Coordinates 2205907..2206116 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag E3I93_RS11380 Protein ID WP_000138934.1
Coordinates 2206128..2206421 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3I93_RS11355 2201796..2202866 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
E3I93_RS11360 2203184..2204386 + 1203 WP_001109939.1 rod shape-determining protein RodA -
E3I93_RS11365 2204547..2205230 - 684 Protein_2110 transposase -
E3I93_RS11370 2205642..2205779 - 138 WP_000828354.1 hypothetical protein -
E3I93_RS11375 2205907..2206116 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
E3I93_RS11380 2206128..2206421 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3I93_RS11385 2206587..2208071 + 1485 WP_000571560.1 cardiolipin synthase -
E3I93_RS11390 2208099..2208746 + 648 WP_001187612.1 HD domain-containing protein -
E3I93_RS11405 2209359..2210231 - 873 WP_000725802.1 membrane protein insertase YidC -
E3I93_RS11410 2210317..2210958 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2204547..2204723 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T120664 WP_000581791.1 NZ_CP038021:c2206116-2205907 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T120664 NZ_CP038021:c2206116-2205907 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT120664 WP_000138934.1 NZ_CP038021:c2206421-2206128 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT120664 NZ_CP038021:c2206421-2206128 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References