120650

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1894689..1895383 Replicon chromosome
Accession NZ_CP038018
Organism Eikenella exigua strain PXX

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EZJ17_RS09625 Protein ID WP_151086478.1
Coordinates 1894689..1894880 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EZJ17_RS09630 Protein ID WP_151086480.1
Coordinates 1894967..1895383 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EZJ17_RS09610 1889828..1892023 + 2196 WP_151086473.1 TIGR01666 family membrane protein -
EZJ17_RS09615 1892324..1893364 - 1041 WP_151086475.1 tRNA dihydrouridine(20/20a) synthase DusA -
EZJ17_RS09620 1893456..1894604 + 1149 WP_067439757.1 tyrosine-type recombinase/integrase -
EZJ17_RS09625 1894689..1894880 + 192 WP_151086478.1 type II toxin-antitoxin system HicA family toxin Toxin
EZJ17_RS09630 1894967..1895383 + 417 WP_151086480.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EZJ17_RS09635 1895437..1896237 - 801 WP_151086483.1 DNA adenine methylase -
EZJ17_RS09640 1896338..1896835 - 498 WP_151086485.1 DUF2514 family protein -
EZJ17_RS09645 1896842..1897009 - 168 WP_082887735.1 photosystem I reaction center subunit PsaK -
EZJ17_RS10375 1897086..1897250 - 165 WP_167508187.1 hypothetical protein -
EZJ17_RS09650 1897252..1897800 - 549 WP_151086487.1 TIGR02594 family protein -
EZJ17_RS09655 1898120..1898383 - 264 WP_151086330.1 hypothetical protein -
EZJ17_RS09660 1898371..1898760 - 390 WP_151086489.1 hypothetical protein -
EZJ17_RS09665 1898757..1898999 - 243 WP_067445017.1 hypothetical protein -
EZJ17_RS09670 1898996..1899700 - 705 WP_151086491.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1885913..1935404 49491


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-129)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7148.35 Da        Isoelectric Point: 10.9812

>T120650 WP_151086478.1 NZ_CP038018:1894689-1894880 [Eikenella exigua]
MKNSHEIIKALKADGWELKRVNGSHHIFYKPGAKFPITISHPNKNLSIGQIKDAERKSGLKLR

Download         Length: 192 bp

>T120650 NZ_CP038018:1894689-1894880 [Eikenella exigua]
ATGAAAAACAGCCACGAAATCATCAAAGCCCTGAAAGCCGACGGGTGGGAACTGAAAAGAGTAAACGGTAGCCACCATAT
ATTTTACAAGCCAGGCGCAAAATTCCCAATCACCATATCCCACCCAAATAAAAATCTATCAATAGGCCAGATAAAGGATG
CAGAAAGGAAATCAGGACTAAAACTAAGATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15037.81 Da        Isoelectric Point: 4.1805

>AT120650 WP_151086480.1 NZ_CP038018:1894967-1895383 [Eikenella exigua]
MKAFALAIYKDADNPTYGVVVPDVPGCYPCGDTIEAAIEDSKAAIKAHIEFMLENDLEVDLTTHSIEELRANADYADAIA
WGIAEIDESNLSAKQTRFNVSWPEYLLDKVDRFAAENHDTRSGFLAKAALAAIDKTAG

Download         Length: 417 bp

>AT120650 NZ_CP038018:1894967-1895383 [Eikenella exigua]
ATGAAAGCATTTGCATTAGCCATCTATAAAGATGCAGACAATCCCACTTACGGCGTAGTCGTGCCGGATGTGCCGGGCTG
TTATCCCTGCGGCGACACCATCGAGGCCGCCATTGAGGACAGCAAGGCAGCCATCAAAGCGCATATTGAATTTATGCTGG
AGAACGATTTAGAAGTAGACTTAACCACGCACTCGATTGAAGAATTACGAGCCAATGCCGATTATGCCGATGCCATAGCA
TGGGGCATTGCCGAAATCGACGAGAGCAACCTATCCGCCAAGCAAACCCGCTTTAACGTCAGCTGGCCTGAATACCTGCT
GGATAAGGTTGACCGCTTCGCCGCCGAAAATCACGATACCCGCTCCGGCTTTTTAGCCAAAGCTGCGCTGGCGGCCATCG
ATAAAACGGCCGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References