Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 3135378..3135996 Replicon chromosome
Accession NZ_CP038012
Organism Sporosarcina pasteurii strain BNCC 337394

Toxin (Protein)


Gene name pemK Uniprot ID A0A380CGL8
Locus tag E2C16_RS15140 Protein ID WP_075526783.1
Coordinates 3135646..3135996 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag E2C16_RS15135 Protein ID WP_115364178.1
Coordinates 3135378..3135641 (+) Length 88 a.a.

Genomic Context

E2C16_RS15120E2C16_RS15125E2C16_RS15130E2C16_RS15135E2C16_RS15140E2C16_RS15145E2C16_RS15150E2C16_RS15155E2C16_RS15160E2C16_RS15165E2C16_RS15170E2C16_RS15175E2C16_RS15115
Location: 3132488..3132841 (354 bp)
Type: Others
Protein ID: WP_115363354.1
Location: 3132900..3133997 (1098 bp)
Type: Others
Protein ID: WP_115363352.1
Location: 3134088..3135215 (1128 bp)
Type: Others
Protein ID: WP_115363350.1
Location: 3135378..3135641 (264 bp)
Type: Antitoxin
Protein ID: WP_115364178.1
Location: 3135646..3135996 (351 bp)
Type: Toxin
Protein ID: WP_075526783.1
Location: 3136145..3136975 (831 bp)
Type: Others
Protein ID: WP_115363348.1
Location: 3136972..3137334 (363 bp)
Type: Others
Protein ID: WP_115363346.1
Location: 3137337..3137738 (402 bp)
Type: Others
Protein ID: WP_115363344.1
Location: 3137754..3138761 (1008 bp)
Type: Others
Protein ID: WP_115363342.1
Location: 3138922..3139263 (342 bp)
Type: Others
Protein ID: WP_115364177.1
Location: 3139250..3139717 (468 bp)
Type: Others
Protein ID: WP_115363340.1
Location: 3139695..3140483 (789 bp)
Type: Others
Protein ID: WP_115363337.1
Location: 3131810..3132421 (612 bp)
Type: Others
Protein ID: WP_115363356.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
E2C16_RS151153131810..3132421-612WP_115363356.1rhomboid family intramembrane serine protease-
E2C16_RS151203132488..3132841+354WP_115363354.1holo-ACP synthase-
E2C16_RS151253132900..3133997+1098WP_115363352.1outer membrane lipoprotein carrier protein LolA-
E2C16_RS151303134088..3135215+1128WP_115363350.1alanine racemase-
E2C16_RS151353135378..3135641+264WP_115364178.1transcriptional regulatorAntitoxin
E2C16_RS151403135646..3135996+351WP_075526783.1type II toxin-antitoxin system PemK/MazF family toxinToxin
E2C16_RS151453136145..3136975+831WP_115363348.1STAS domain-containing protein-
E2C16_RS151503136972..3137334+363WP_115363346.1STAS domain-containing protein-
E2C16_RS151553137337..3137738+402WP_115363344.1anti-sigma regulatory factor-
E2C16_RS151603137754..3138761+1008WP_115363342.1PP2C family protein-serine/threonine phosphatase-
E2C16_RS151653138922..3139263+342WP_115364177.1STAS domain-containing protein-
E2C16_RS151703139250..3139717+468WP_115363340.1anti-sigma B factor RsbW-
E2C16_RS151753139695..3140483+789WP_115363337.1RNA polymerase sigma factor SigB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12985.01 Da        Isoelectric Point: 4.9105

>T120644 WP_075526783.1 NZ_CP038012:3135646-3135996 [Sporosarcina pasteurii]
MAIKRGDVFFADLSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAEKYQFERDSVILLEQV
RTIDKSRLTDKITHLDEMLMEKVDEALEVSFGLVKF

Download         Length: 351 bp

>T120644 NZ_CP038012:3135646-3135996 [Sporosarcina pasteurii]
TTGGCAATAAAACGAGGAGACGTCTTTTTTGCAGACCTGTCGCCGGTCGTTGGTTCTGAGCAAGGGGGTACCAGACCGGT
CCTTGTCATACAAAATGACATTGGGAACCGGTTTAGTCCAACTGTAATTATCGCAGCCATTACTGCACAGATTCAGAAAG
CAAAGTTGCCGACACATGTAGAAATCGATGCGGAAAAGTATCAATTCGAGCGGGACTCTGTAATCCTGCTCGAACAAGTC
CGCACGATTGATAAGTCGAGGTTAACTGATAAAATTACGCATCTTGATGAAATGTTGATGGAAAAAGTCGACGAAGCATT
AGAAGTAAGTTTTGGGCTCGTAAAATTTTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10141.58 Da        Isoelectric Point: 6.3281

>AT120644 WP_115364178.1 NZ_CP038012:3135378-3135641 [Sporosarcina pasteurii]
MREVIVKIPKRMLNENEHTVVHQGQERGDFVYISTKRYETNHEPEAIREAMMKGYVEMSQINLKIATECLHVEFEAQHTV
ERLVSGG

Download         Length: 264 bp

>AT120644 NZ_CP038012:3135378-3135641 [Sporosarcina pasteurii]
ATGAGAGAGGTTATTGTTAAAATTCCGAAACGAATGTTGAATGAAAATGAACATACGGTCGTCCACCAAGGGCAGGAGCG
AGGGGATTTTGTATATATTTCGACAAAACGCTATGAGACCAATCATGAACCTGAGGCAATTCGAGAGGCCATGATGAAAG
GGTATGTTGAAATGTCGCAAATTAACTTAAAAATTGCCACGGAATGTTTACATGTGGAATTTGAAGCTCAGCACACAGTG
GAACGTCTCGTTAGCGGAGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A380CGL8

Antitoxin

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Source
ID
Structure
No matching records found

References