120643

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 3931..4519 Replicon plasmid pAHTJR2
Accession NZ_CP038011
Organism Acinetobacter haemolyticus strain TJR01

Toxin (Protein)


Gene name brnT Uniprot ID A0A4P7BB87
Locus tag AHTJR_RS17655 Protein ID WP_068553177.1
Coordinates 4232..4519 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID A0A0U3TC92
Locus tag AHTJR_RS17650 Protein ID WP_032038670.1
Coordinates 3931..4245 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AHTJR_RS17635 2014..2703 + 690 WP_134253138.1 AAA family ATPase -
AHTJR_RS17640 2891..3175 + 285 WP_134253139.1 ATP-binding protein -
AHTJR_RS17645 3172..3858 + 687 WP_134253140.1 hypothetical protein -
AHTJR_RS17650 3931..4245 - 315 WP_032038670.1 BrnA antitoxin family protein Antitoxin
AHTJR_RS17655 4232..4519 - 288 WP_068553177.1 BrnT family toxin Toxin
AHTJR_RS17660 4957..6345 - 1389 Protein_6 NAD(P)/FAD-dependent oxidoreductase -
AHTJR_RS17665 6362..7108 - 747 Protein_7 S-formylglutathione hydrolase -
AHTJR_RS17675 7661..8058 - 398 Protein_8 VOC family protein -
AHTJR_RS17680 8111..9217 - 1107 Protein_9 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
AHTJR_RS17685 9239..9514 - 276 WP_031983787.1 metal/formaldehyde-sensitive transcriptional repressor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..13835 13835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11262.66 Da        Isoelectric Point: 5.6153

>T120643 WP_068553177.1 NZ_CP038011:c4519-4232 [Acinetobacter haemolyticus]
MEQYFEWDEAKNRKNQKKHDISFETASLVFDDPLRISIQDRHTDGEERWQTIGKVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T120643 NZ_CP038011:c4519-4232 [Acinetobacter haemolyticus]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTCTTTGATGATCCTCTAAGGATCTCAATTCAGGACAGACATACCGATGGCGAAGAACGTTGGCAGACCATTGGAA
AAGTGAAAGGCGTACTAATGCTCTTAGTAGCTCATACCATCTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCAAGGCAAGTCACCAAGGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12269.00 Da        Isoelectric Point: 9.4646

>AT120643 WP_032038670.1 NZ_CP038011:c4245-3931 [Acinetobacter haemolyticus]
MSMVRYSRKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDMPEITDWSNAVRHNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKKHQ

Download         Length: 315 bp

>AT120643 NZ_CP038011:c4245-3931 [Acinetobacter haemolyticus]
ATGAGCATGGTTAGATACTCACGCAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACTGTTCCTGATGATCAGCTAGATCTCTCAGATATGCCTGAAATTACCGACTGGAGCAATGCTGTACGCC
ACAATCAATTCTATCGACCAGTGAAGCAACAAACATCTATTCGTTTAGATGCTGACGTACTTGCATGGTTCAAAGCACAA
GGTAAAGGTTATCAGACACGCATGAATGAAATCTTGCGGGATGCCATGCTAAAAGAATTAAAAAAACATCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7BB87

Antitoxin

Source ID Structure
AlphaFold DB A0A0U3TC92

References