120640

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1634238..1635370 Replicon chromosome
Accession NZ_CP038009
Organism Acinetobacter haemolyticus strain TJR01

Toxin (Protein)


Gene name - Uniprot ID C0VPL6
Locus tag AHTJR_RS07785 Protein ID WP_004639220.1
Coordinates 1634238..1635002 (-) Length 255 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID N9FA41
Locus tag AHTJR_RS07790 Protein ID WP_004639219.1
Coordinates 1634999..1635370 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AHTJR_RS07760 1630147..1631004 + 858 WP_004639225.1 3-deoxy-8-phosphooctulonate synthase -
AHTJR_RS07765 1631095..1632384 + 1290 WP_004639224.1 phosphopyruvate hydratase -
AHTJR_RS07770 1632514..1632879 + 366 WP_004639223.1 cell division protein FtsB -
AHTJR_RS07775 1632869..1633576 + 708 WP_134252218.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
AHTJR_RS07780 1633703..1634179 + 477 WP_005090442.1 hypothetical protein -
AHTJR_RS07785 1634238..1635002 - 765 WP_004639220.1 RES family NAD+ phosphorylase Toxin
AHTJR_RS07790 1634999..1635370 - 372 WP_004639219.1 DUF2384 domain-containing protein Antitoxin
AHTJR_RS07795 1635586..1635999 + 414 WP_005080585.1 YeeE/YedE family protein -
AHTJR_RS07800 1636001..1636414 + 414 WP_005090445.1 YeeE/YedE family protein -
AHTJR_RS07805 1636429..1637301 + 873 WP_017396076.1 MBL fold metallo-hydrolase -
AHTJR_RS07810 1637470..1638168 + 699 WP_005080590.1 phosphoglycerate mutase family protein -
AHTJR_RS07815 1638310..1638570 + 261 WP_005080592.1 hypothetical protein -
AHTJR_RS07820 1638697..1639281 + 585 WP_134252220.1 uracil-DNA glycosylase family protein -
AHTJR_RS07825 1639278..1639766 - 489 WP_134252221.1 pyridoxamine 5'-phosphate oxidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(68-206)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(73-121)


Sequences

Toxin        


Download         Length: 255 a.a.        Molecular weight: 29094.01 Da        Isoelectric Point: 5.5775

>T120640 WP_004639220.1 NZ_CP038009:c1635002-1634238 [Acinetobacter haemolyticus]
MTAIEQNLWQSCEGNKQVSPLSGTLYRLVESQEQIATRQLVDTLEEQALLEDMLELVKPPYPPKSEHLHYLLKTPFRYPP
LKWGSRFGRTFEPSIFYGGCSVNVTLAESAYYRFVFWYSMDGAPKKKTIRTEHTLFSVGYHCHKGIRLQSPPFDQYLDLI
AHPTNYSYAQLLGTAMRNEGVEIFEYPSARASDHATCVGLFTAEHFSQNSPLDREQWFCDIGAEEVIFKAVEGSDIVRFE
LSQFLQQGIFPMPA

Download         Length: 765 bp

>T120640 NZ_CP038009:c1635002-1634238 [Acinetobacter haemolyticus]
ATGACCGCCATTGAGCAAAATTTATGGCAAAGTTGTGAAGGAAACAAACAAGTCTCACCTTTATCAGGTACTTTATATCG
TCTAGTTGAAAGCCAAGAACAAATTGCAACTAGGCAGTTGGTTGATACTTTAGAAGAACAAGCATTGCTCGAGGATATGT
TAGAGTTAGTTAAACCACCATATCCTCCAAAGTCAGAGCATTTACATTACCTACTCAAAACACCATTTCGTTATCCACCG
TTAAAATGGGGATCACGTTTCGGTCGTACTTTTGAACCCAGTATTTTTTATGGTGGGTGTAGTGTCAATGTGACATTGGC
TGAATCAGCTTATTATCGCTTTGTATTCTGGTACTCAATGGATGGTGCACCAAAGAAAAAAACGATACGCACTGAGCATA
CTTTATTTTCAGTAGGCTATCACTGCCATAAGGGTATTCGTTTACAATCCCCTCCTTTTGACCAATATCTGGATTTAATT
GCTCATCCTACAAATTATAGTTATGCACAACTATTAGGTACAGCAATGCGGAATGAAGGAGTTGAGATCTTTGAGTATCC
GTCAGCTCGAGCAAGTGATCATGCTACCTGTGTCGGATTATTCACCGCAGAGCATTTCAGCCAGAATAGCCCTTTAGATC
GAGAACAATGGTTCTGTGACATAGGTGCTGAAGAAGTTATATTTAAAGCAGTAGAAGGATCTGATATCGTTCGCTTTGAA
TTATCGCAGTTTTTACAACAAGGTATTTTTCCAATGCCTGCATAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13291.58 Da        Isoelectric Point: 10.4005

>AT120640 WP_004639219.1 NZ_CP038009:c1635370-1634999 [Acinetobacter haemolyticus]
MSALLKQPADKKVVLAKAVLSAAEQLDLKQVQLAAILGVHRTAISRLKNNPELDPASKQGELALLLIRLSRALYALTGGD
TDWMRHFLNTPNRVTGGIPVEQIESISGLVSVLQFVDAIRGKV

Download         Length: 372 bp

>AT120640 NZ_CP038009:c1635370-1634999 [Acinetobacter haemolyticus]
ATGAGTGCATTATTAAAACAACCCGCAGATAAAAAAGTAGTTCTTGCAAAAGCAGTACTCAGTGCCGCTGAGCAACTTGA
TTTAAAGCAAGTACAACTTGCCGCCATTTTAGGTGTACATCGCACAGCGATTAGTCGATTGAAAAATAATCCTGAATTAG
ATCCCGCATCTAAACAAGGTGAGTTAGCATTGCTTCTTATTCGTTTATCACGCGCATTGTATGCACTAACTGGCGGAGAC
ACGGATTGGATGCGTCATTTTTTGAACACACCAAATCGTGTTACAGGTGGTATTCCTGTTGAACAAATTGAAAGTATAAG
TGGACTGGTTTCAGTTCTTCAATTTGTCGATGCGATTCGAGGTAAAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A372MQ11

Antitoxin

Source ID Structure
AlphaFold DB N9FA41

References