Detailed information of TA system TA120638

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 324298..324906
• Replicon: chromosome
• Accession: NZ_CP038009
• Organism: Acinetobacter haemolyticus strain TJR01

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AHTJR_RS01490
• Protein ID: WP_134251350.1
• Coordinates: 324508..324906 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1L6KJB8
• Locus tag: AHTJR_RS01485
• Protein ID: WP_008941147.1
• Coordinates: 324298..324507 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AHTJR_RS01460	319348..320769	+	1422	WP_075314555.1	FAD-dependent oxidoreductase	-
AHTJR_RS01465	320940..321830	+	891	WP_005088504.1	metal-dependent hydrolase	-
AHTJR_RS01470	322004..322594	+	591	WP_004641306.1	LemA family protein	-
AHTJR_RS01475	322619..323671	+	1053	WP_134251346.1	TPM domain-containing protein	-
AHTJR_RS01480	323665..324225	+	561	WP_134251348.1	TPM domain-containing protein	-
AHTJR_RS01485	324298..324507	+	210	WP_008941147.1	antitoxin	Antitoxin
AHTJR_RS01490	324508..324906	+	399	WP_134251350.1	tRNA(fMet)-specific endonuclease VapC	Toxin
AHTJR_RS01495	325295..325777	+	483	WP_134251352.1	pilin	-
AHTJR_RS01500	325863..327020	+	1158	WP_166739941.1	serine hydrolase	-
AHTJR_RS01505	327126..327866	+	741	WP_134251356.1	type IV pilin accessory protein	-
AHTJR_RS01510	327875..328828	+	954	WP_134251358.1	acyltransferase	-
AHTJR_RS01515	328969..329394	+	426	WP_134253072.1	pilin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14862.19 Da
• Isoelectric Point: 8.9036

>T120638 WP_134251350.1 NZ_CP038009:324508-324906 [Acinetobacter haemolyticus]
MLKYMLDTNIVIYTMKQRPLAVKERFNAVSTQLCVSSITVAESIFGAENSQTPAKNLKVVEDFLSRLQILDYGVDAAIQY
GNIKAQLKRIGQPIGENDLHIAAHARSRGLILVTNNMREFERVPALQVENWT

Nucleotide

• Length: 399 bp

>T120638 NZ_CP038009:324508-324906 [Acinetobacter haemolyticus]
ATGCTGAAATATATGCTGGATACCAATATTGTGATTTATACAATGAAACAAAGACCATTGGCGGTTAAAGAAAGGTTTAA
TGCCGTCTCAACACAACTCTGCGTTAGTAGTATCACGGTTGCGGAATCAATTTTTGGGGCGGAAAATAGCCAAACTCCTG
CGAAGAATTTAAAAGTTGTAGAAGACTTTTTATCACGATTGCAAATCTTGGATTATGGCGTAGATGCTGCAATCCAATAT
GGAAATATTAAAGCTCAGCTAAAAAGAATAGGTCAACCGATTGGCGAGAATGATCTACATATCGCAGCTCATGCGAGAAG
TAGGGGATTGATTTTGGTGACAAATAATATGAGAGAGTTTGAGCGTGTGCCTGCATTACAGGTAGAAAACTGGACTTAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8155.02 Da
• Isoelectric Point: 4.2702

>AT120638 WP_008941147.1 NZ_CP038009:324298-324507 [Acinetobacter haemolyticus]
MNNRTQAVRLPSIYRFSETTQKVFVRQVGVERVISPVEQVWDSFFEDPELQLSDDFERGEQISAERESF

Nucleotide

• Length: 210 bp

>AT120638 NZ_CP038009:324298-324507 [Acinetobacter haemolyticus]
ATGAATAATCGTACCCAAGCAGTAAGACTACCGAGTATTTATCGTTTTTCTGAAACAACTCAAAAAGTTTTTGTGCGACA
GGTGGGGGTTGAGCGAGTGATTAGCCCAGTCGAACAGGTTTGGGATAGTTTTTTCGAAGATCCTGAGTTACAACTTTCAG
ATGACTTTGAGCGCGGTGAACAAATTTCAGCAGAGAGAGAGTCGTTTTAG

Structures

Antitoxin

• AlphaFold DB: A0A1L6KJB8