Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 4961834..4962438 Replicon chromosome
Accession NZ_CP038001
Organism Pseudomonas sp. SXM-1

Toxin (Protein)


Gene name hicA Uniprot ID A0A143GE94
Locus tag DCC84_RS23190 Protein ID WP_063028501.1
Coordinates 4961834..4962085 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A829N1T3
Locus tag DCC84_RS23195 Protein ID WP_003208166.1
Coordinates 4962082..4962438 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCC84_RS23190 4961834..4962085 + 252 WP_063028501.1 type II toxin-antitoxin system HicA family toxin Toxin
DCC84_RS23195 4962082..4962438 + 357 WP_003208166.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DCC84_RS23200 4962439..4963611 - 1173 WP_102369571.1 MFS transporter -
DCC84_RS23205 4963746..4964330 + 585 WP_134327028.1 TetR/AcrR family transcriptional regulator -
DCC84_RS23220 4965238..4966746 - 1509 WP_134327029.1 multidrug efflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9493.00 Da        Isoelectric Point: 10.0940

>T120634 WP_063028501.1 NZ_CP038001:4961834-4962085 [Pseudomonas sp. SXM-1]
VSKNEKLLAKLLNEQSAFTWPELVTLLRRLGYTQIEGAGSRVRFDIGDPSAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

>T120634 NZ_CP038001:4961834-4962085 [Pseudomonas sp. SXM-1]
GTGTCGAAAAATGAAAAGCTGCTGGCCAAACTGCTCAATGAGCAATCGGCCTTTACCTGGCCCGAACTCGTCACGCTGCT
GCGGCGCCTGGGATACACGCAAATCGAAGGGGCGGGTAGCCGGGTCAGGTTCGACATAGGCGACCCCAGTGCAATGATCA
CCCTGCACAAGCCTCACCCCGGCAACGAACTGAAACACTACATTCGGCGCCAGATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12788.62 Da        Isoelectric Point: 6.8428

>AT120634 WP_003208166.1 NZ_CP038001:4962082-4962438 [Pseudomonas sp. SXM-1]
VNNQLKHKGYIGSIEASIEDNCLFGKLLFIKALVSYEGKTVAELDAAFCTAVDDYIETCQALGQAPEKPCKGSFNVRVGH
DLHLAAALAATRQKVTLNDLTRQALNEFLQHRGALVTG

Download         Length: 357 bp

>AT120634 NZ_CP038001:4962082-4962438 [Pseudomonas sp. SXM-1]
GTGAACAACCAGCTGAAACACAAAGGCTACATCGGCTCCATCGAAGCCAGCATCGAAGACAACTGCCTGTTCGGAAAGCT
GCTTTTCATCAAGGCCCTGGTCAGCTACGAGGGCAAAACCGTCGCCGAACTGGACGCCGCCTTTTGCACCGCCGTGGACG
ACTACATCGAGACCTGCCAGGCCCTTGGGCAAGCACCGGAAAAGCCCTGCAAGGGTTCGTTCAACGTCCGTGTCGGCCAT
GACCTCCACCTGGCCGCCGCCCTCGCCGCGACCCGGCAAAAAGTCACGTTGAACGATCTCACGCGCCAGGCGCTGAACGA
ATTCCTGCAACATCGCGGCGCACTGGTGACCGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143GE94

Antitoxin

Source ID Structure
AlphaFold DB A0A829N1T3

References