Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 701334..701927 Replicon chromosome
Accession NZ_CP038001
Organism Pseudomonas sp. SXM-1

Toxin (Protein)


Gene name relE Uniprot ID A0A2N7Y341
Locus tag DCC84_RS03175 Protein ID WP_008439032.1
Coordinates 701625..701927 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2N7Y2X0
Locus tag DCC84_RS03170 Protein ID WP_008439033.1
Coordinates 701334..701621 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCC84_RS03150 697710..699782 - 2073 WP_134325663.1 TonB-dependent copper receptor -
DCC84_RS03155 699876..700247 - 372 WP_102607479.1 DUF2946 domain-containing protein -
DCC84_RS03160 700312..700794 - 483 WP_076017993.1 copper chaperone PCu(A)C -
DCC84_RS03165 700841..701236 - 396 WP_008439034.1 DUF2946 domain-containing protein -
DCC84_RS03170 701334..701621 - 288 WP_008439033.1 putative addiction module antidote protein Antitoxin
DCC84_RS03175 701625..701927 - 303 WP_008439032.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DCC84_RS34310 702343..702543 + 201 WP_158213535.1 hypothetical protein -
DCC84_RS03180 702572..702823 + 252 WP_087693137.1 hypothetical protein -
DCC84_RS03185 702945..703664 - 720 WP_134325664.1 cobalt-precorrin-6A reductase -
DCC84_RS03190 703661..704866 - 1206 WP_102368009.1 precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE -
DCC84_RS03195 704989..706263 + 1275 WP_134327624.1 precorrin-3B synthase -
DCC84_RS03200 706256..706882 + 627 WP_003217338.1 precorrin-8X methylmutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(2-94)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11558.19 Da        Isoelectric Point: 10.1897

>T120629 WP_008439032.1 NZ_CP038001:c701927-701625 [Pseudomonas sp. SXM-1]
MIHFKKSKHFLEWLDSLNNKPARARVLARLNNAQSGNFGDCETVGNGVSEMRIHYGPGYRVYFTRREEVVYLLLIGGDKS
TQKRDIQRAKQIAADFEKKE

Download         Length: 303 bp

>T120629 NZ_CP038001:c701927-701625 [Pseudomonas sp. SXM-1]
ATGATTCACTTCAAGAAATCCAAGCATTTCCTGGAGTGGCTTGATTCGTTAAACAATAAACCGGCCCGTGCACGCGTACT
GGCAAGGTTGAATAACGCACAATCAGGCAACTTCGGAGACTGTGAGACAGTAGGAAATGGCGTTTCGGAAATGCGCATCC
ACTACGGTCCTGGATACCGGGTTTATTTCACTCGTAGAGAGGAGGTGGTTTACCTGTTGTTGATAGGCGGCGATAAATCA
ACGCAGAAACGCGATATCCAGCGCGCTAAGCAAATTGCAGCAGACTTTGAAAAAAAGGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10280.68 Da        Isoelectric Point: 4.4791

>AT120629 WP_008439033.1 NZ_CP038001:c701621-701334 [Pseudomonas sp. SXM-1]
MTEFTDFDIAEHLKTPEDMAEYLEACFEEDAGDGLLIRSALNNIARAQGMTQVARDAGLGRESLYKALSSTGNPEFATIM
KVMKALGLKLHATAG

Download         Length: 288 bp

>AT120629 NZ_CP038001:c701621-701334 [Pseudomonas sp. SXM-1]
ATGACTGAATTTACAGACTTCGACATAGCGGAACACCTCAAGACTCCTGAAGATATGGCCGAGTATCTTGAAGCGTGCTT
CGAGGAGGATGCCGGTGACGGACTGCTTATTCGTTCAGCCCTCAACAACATCGCCCGCGCCCAAGGCATGACTCAAGTAG
CCCGCGACGCAGGCCTCGGACGCGAAAGTTTATATAAAGCCCTCTCCAGCACTGGCAATCCCGAGTTCGCGACTATCATG
AAGGTCATGAAAGCGCTCGGCCTGAAGCTGCACGCCACAGCTGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N7Y341

Antitoxin

Source ID Structure
AlphaFold DB A0A2N7Y2X0

References