Detailed information of TA system TA120603

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 66944..67503
• Replicon: plasmid psg_wt5
• Accession: NZ_CP037994
• Organism: Salmonella enterica subsp. enterica serovar Albany strain sg_wt5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: U9YB49
• Locus tag: DBZ76_RS24510
• Protein ID: WP_000421259.1
• Coordinates: 66944..67219 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U9Y625
• Locus tag: DBZ76_RS24515
• Protein ID: WP_001178087.1
• Coordinates: 67219..67503 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBZ76_RS24475	62656..62910	+	255	WP_000343106.1	hypothetical protein	-
DBZ76_RS24480	62910..63500	+	591	WP_001401589.1	hypothetical protein	-
DBZ76_RS24485	63713..64765	+	1053	WP_000655519.1	hypothetical protein	-
DBZ76_RS24490	64941..65543	+	603	WP_000521606.1	hypothetical protein	-
DBZ76_RS24495	65599..66093	+	495	WP_015058884.1	hypothetical protein	-
DBZ76_RS24800	66093..66359	+	267	WP_000627832.1	hypothetical protein	-
DBZ76_RS24505	66551..66838	-	288	WP_130046600.1	hypothetical protein	-
DBZ76_RS24510	66944..67219	-	276	WP_000421259.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DBZ76_RS24515	67219..67503	-	285	WP_001178087.1	ribbon-helix-helix protein, CopG family	Antitoxin
DBZ76_RS24535	68407..69438	-	1032	WP_000907852.1	replication initiation protein	-
DBZ76_RS24550	70411..70674	+	264	WP_001324596.1	ash family protein	-
DBZ76_RS24555	70592..70879	+	288	WP_000074849.1	conjugal transfer protein TraA	-
DBZ76_RS24565	71321..71854	+	534	WP_001372168.1	transcription termination factor NusG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..84511	84511

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Antitoxin

• Ribbon-helix-helix protein, CopG (12-45)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 13558.26 Da
• Isoelectric Point: 5.5500

>T120603 WP_000421259.1 NZ_CP037994:c67219-66944 [Salmonella enterica subsp. enterica serovar Albany]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFF

Nucleotide

• Length: 276 bp

>T120603 NZ_CP037994:c67219-66944 [Salmonella enterica subsp. enterica serovar Albany]
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Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 13999.79 Da
• Isoelectric Point: 5.5500

>AT120603 WP_001178087.1 NZ_CP037994:c67503-67219 [Salmonella enterica subsp. enterica serovar Albany]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFF

Nucleotide

• Length: 285 bp

>AT120603 NZ_CP037994:c67503-67219 [Salmonella enterica subsp. enterica serovar Albany]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: U9YB49

Antitoxin

• AlphaFold DB: U9Y625