Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/upstrm_HI1419-dnstrm_HI1420 |
Location | 162025..162680 | Replicon | chromosome |
Accession | NZ_CP037970 | ||
Organism | Burkholderia pseudomallei strain BPs123 |
Toxin (Protein)
Gene name | relE | Uniprot ID | B1H687 |
Locus tag | E2R23_RS16915 | Protein ID | WP_004532728.1 |
Coordinates | 162384..162680 (-) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | Q63YL3 |
Locus tag | E2R23_RS16910 | Protein ID | WP_004202809.1 |
Coordinates | 162025..162381 (-) | Length | 119 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E2R23_RS16890 | 157257..158173 | - | 917 | Protein_159 | phage major capsid protein, P2 family | - |
E2R23_RS16895 | 158207..159016 | - | 810 | WP_015985028.1 | GPO family capsid scaffolding protein | - |
E2R23_RS16900 | 159160..160929 | + | 1770 | WP_134220717.1 | terminase ATPase subunit family protein | - |
E2R23_RS16905 | 160926..161981 | + | 1056 | WP_038737788.1 | phage portal protein | - |
E2R23_RS16910 | 162025..162381 | - | 357 | WP_004202809.1 | putative addiction module antidote protein | Antitoxin |
E2R23_RS16915 | 162384..162680 | - | 297 | WP_004532728.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
E2R23_RS16930 | 163833..164567 | + | 735 | WP_131117334.1 | 7-cyano-7-deazaguanine synthase QueC | - |
E2R23_RS16935 | 164661..165293 | + | 633 | WP_131117337.1 | 7-carboxy-7-deazaguanine synthase | - |
E2R23_RS16940 | 165313..165765 | + | 453 | WP_004189793.1 | 6-carboxytetrahydropterin synthase QueD | - |
E2R23_RS16950 | 166185..166970 | + | 786 | WP_004189570.1 | 2-dehydro-3-deoxyglucarate aldolase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 135690..165293 | 29603 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 10876.71 Da Isoelectric Point: 10.1723
>T120589 WP_004532728.1 NZ_CP037970:c162680-162384 [Burkholderia pseudomallei]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFMRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFMRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED
Download Length: 297 bp
>T120589 NZ_CP037970:c162680-162384 [Burkholderia pseudomallei]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTCGACGGGCTTCGCGACCCGGTCGGTAGCGCGGCGATCAA
CCTGCGCATTGAGCGGGCAAAGCTTGGCAATCTCGGCCAATGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCATGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGTGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTCGACGGGCTTCGCGACCCGGTCGGTAGCGCGGCGATCAA
CCTGCGCATTGAGCGGGCAAAGCTTGGCAATCTCGGCCAATGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCATGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGTGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA
Antitoxin
Download Length: 119 a.a. Molecular weight: 12585.41 Da Isoelectric Point: 9.9470
>AT120589 WP_004202809.1 NZ_CP037970:c162381-162025 [Burkholderia pseudomallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA
Download Length: 357 bp
>AT120589 NZ_CP037970:c162381-162025 [Burkholderia pseudomallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | B1H687 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3N4G1D3 |