Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 162025..162680 Replicon chromosome
Accession NZ_CP037970
Organism Burkholderia pseudomallei strain BPs123

Toxin (Protein)


Gene name relE Uniprot ID B1H687
Locus tag E2R23_RS16915 Protein ID WP_004532728.1
Coordinates 162384..162680 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag E2R23_RS16910 Protein ID WP_004202809.1
Coordinates 162025..162381 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E2R23_RS16890 157257..158173 - 917 Protein_159 phage major capsid protein, P2 family -
E2R23_RS16895 158207..159016 - 810 WP_015985028.1 GPO family capsid scaffolding protein -
E2R23_RS16900 159160..160929 + 1770 WP_134220717.1 terminase ATPase subunit family protein -
E2R23_RS16905 160926..161981 + 1056 WP_038737788.1 phage portal protein -
E2R23_RS16910 162025..162381 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
E2R23_RS16915 162384..162680 - 297 WP_004532728.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E2R23_RS16930 163833..164567 + 735 WP_131117334.1 7-cyano-7-deazaguanine synthase QueC -
E2R23_RS16935 164661..165293 + 633 WP_131117337.1 7-carboxy-7-deazaguanine synthase -
E2R23_RS16940 165313..165765 + 453 WP_004189793.1 6-carboxytetrahydropterin synthase QueD -
E2R23_RS16950 166185..166970 + 786 WP_004189570.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 135690..165293 29603


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10876.71 Da        Isoelectric Point: 10.1723

>T120589 WP_004532728.1 NZ_CP037970:c162680-162384 [Burkholderia pseudomallei]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFMRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T120589 NZ_CP037970:c162680-162384 [Burkholderia pseudomallei]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTCGACGGGCTTCGCGACCCGGTCGGTAGCGCGGCGATCAA
CCTGCGCATTGAGCGGGCAAAGCTTGGCAATCTCGGCCAATGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCATGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGTGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT120589 WP_004202809.1 NZ_CP037970:c162381-162025 [Burkholderia pseudomallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT120589 NZ_CP037970:c162381-162025 [Burkholderia pseudomallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1H687

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References