Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1395478..1396133 Replicon chromosome
Accession NZ_CP037969
Organism Burkholderia pseudomallei strain BPs123

Toxin (Protein)


Gene name relE Uniprot ID B1H687
Locus tag E2R23_RS07100 Protein ID WP_004532728.1
Coordinates 1395478..1395774 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag E2R23_RS07105 Protein ID WP_004202809.1
Coordinates 1395777..1396133 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E2R23_RS07065 1390898..1392283 - 1386 WP_004197873.1 TolC family protein -
E2R23_RS07075 1392502..1392786 - 285 WP_004532722.1 hypothetical protein -
E2R23_RS07080 1393184..1393324 - 141 WP_004524134.1 bacteriophage protein -
E2R23_RS07090 1393977..1394465 - 489 WP_004528293.1 adenosine-specific kinase -
E2R23_RS07095 1394797..1395282 + 486 WP_004197880.1 YbaK/EbsC family protein -
E2R23_RS07100 1395478..1395774 + 297 WP_004532728.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E2R23_RS07105 1395777..1396133 + 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
E2R23_RS07110 1396177..1397232 - 1056 WP_023359646.1 phage portal protein -
E2R23_RS07115 1397229..1398977 - 1749 WP_134220565.1 terminase ATPase subunit family protein -
E2R23_RS07120 1399121..1399902 + 782 Protein_1120 GPO family capsid scaffolding protein -
E2R23_RS07125 1399936..1400946 + 1011 WP_134220566.1 phage major capsid protein, P2 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1393184..1418687 25503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10876.71 Da        Isoelectric Point: 10.1723

>T120587 WP_004532728.1 NZ_CP037969:1395478-1395774 [Burkholderia pseudomallei]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFMRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T120587 NZ_CP037969:1395478-1395774 [Burkholderia pseudomallei]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTCGACGGGCTTCGCGACCCGGTCGGTAGCGCGGCGATCAA
CCTGCGCATTGAGCGGGCAAAGCTTGGCAATCTCGGCCAATGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCATGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGTGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT120587 WP_004202809.1 NZ_CP037969:1395777-1396133 [Burkholderia pseudomallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT120587 NZ_CP037969:1395777-1396133 [Burkholderia pseudomallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1H687

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References