Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4629643..4630159 Replicon chromosome
Accession NZ_CP037963
Organism Klebsiella pneumoniae strain SCKP020135

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag CLQ43_RS22940 Protein ID WP_004178374.1
Coordinates 4629643..4629927 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CLQ43_RS22945 Protein ID WP_002886901.1
Coordinates 4629917..4630159 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLQ43_RS22920 4625038..4625346 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
CLQ43_RS29025 4625431..4625604 + 174 WP_032412860.1 hypothetical protein -
CLQ43_RS22925 4625607..4626350 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CLQ43_RS22930 4626707..4628845 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
CLQ43_RS22935 4629175..4629639 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CLQ43_RS22940 4629643..4629927 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CLQ43_RS22945 4629917..4630159 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CLQ43_RS22950 4630237..4632147 - 1911 WP_004152270.1 BglG family transcription antiterminator -
CLQ43_RS22955 4632170..4633324 - 1155 WP_002886900.1 lactonase family protein -
CLQ43_RS22960 4633391..4634131 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T120580 WP_004178374.1 NZ_CP037963:c4629927-4629643 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T120580 NZ_CP037963:c4629927-4629643 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT120580 WP_002886901.1 NZ_CP037963:c4630159-4629917 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT120580 NZ_CP037963:c4630159-4629917 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References