Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3906416..3907035 Replicon chromosome
Accession NZ_CP037963
Organism Klebsiella pneumoniae strain SCKP020135

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag CLQ43_RS19470 Protein ID WP_002892050.1
Coordinates 3906817..3907035 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag CLQ43_RS19465 Protein ID WP_002892066.1
Coordinates 3906416..3906790 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLQ43_RS19455 3901568..3902761 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CLQ43_RS19460 3902784..3905930 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
CLQ43_RS19465 3906416..3906790 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
CLQ43_RS19470 3906817..3907035 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
CLQ43_RS19475 3907198..3907764 + 567 WP_002892030.1 maltose O-acetyltransferase -
CLQ43_RS28900 3907736..3907876 - 141 WP_004147370.1 hypothetical protein -
CLQ43_RS19480 3907897..3908367 + 471 WP_002892026.1 YlaC family protein -
CLQ43_RS19485 3908342..3909793 - 1452 WP_064151794.1 PLP-dependent aminotransferase family protein -
CLQ43_RS19490 3909894..3910592 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
CLQ43_RS19495 3910589..3910729 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
CLQ43_RS19500 3910729..3910992 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T120578 WP_002892050.1 NZ_CP037963:3906817-3907035 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T120578 NZ_CP037963:3906817-3907035 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT120578 WP_002892066.1 NZ_CP037963:3906416-3906790 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT120578 NZ_CP037963:3906416-3906790 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References