Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2700887..2702056 Replicon chromosome
Accession NZ_CP037953
Organism Permianibacter aggregans strain HW001

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag E2H98_RS12000 Protein ID WP_133589193.1
Coordinates 2701292..2702056 (+) Length 255 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag E2H98_RS11995 Protein ID WP_133589195.1
Coordinates 2700887..2701258 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E2H98_RS11970 2696739..2697203 + 465 WP_133589276.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
E2H98_RS11975 2697269..2697634 + 366 WP_198325310.1 hotdog fold thioesterase -
E2H98_RS11980 2697731..2698750 + 1020 WP_133589201.1 hypothetical protein -
E2H98_RS11985 2698747..2700141 + 1395 WP_133589199.1 MBOAT family protein -
E2H98_RS11990 2700198..2700725 - 528 WP_133589197.1 DUF3016 domain-containing protein -
E2H98_RS11995 2700887..2701258 + 372 WP_133589195.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
E2H98_RS12000 2701292..2702056 + 765 WP_133589193.1 RES family NAD+ phosphorylase Toxin
E2H98_RS12005 2702148..2703530 + 1383 WP_133589191.1 LOG family protein -
E2H98_RS12010 2703885..2704346 - 462 WP_133589189.1 hypothetical protein -
E2H98_RS12015 2704456..2705256 - 801 WP_133589187.1 prohibitin family protein -
E2H98_RS12020 2705287..2705487 - 201 WP_133589185.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(66-209)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(6-68)


Sequences

Toxin        


Download         Length: 255 a.a.        Molecular weight: 28830.80 Da        Isoelectric Point: 7.0419

>T120562 WP_133589193.1 NZ_CP037953:2701292-2702056 [Permianibacter aggregans]
MPTRDENIWQRCRGADFIGPMKVEMVRIVEAQEDIATLSLVDNLDEQHLLESLLEKSKPGQLEPNLHYLLASPFRYPPLL
WGSRFGRAHERALFYGSTRMETALAECAFYRLVFIDGVSVPFPQPLVSQHTSFWALARAERAADLTRSPYDSVMAELRAP
DRYSATQILGSEMRSAGVMLFTYRSARDDDPTAINAAAFSPDVFKRAQPTRFQSWTCYATADAVRFISSPNKASHEFSRH
RFLVNERLPMPPPA

Download         Length: 765 bp

>T120562 NZ_CP037953:2701292-2702056 [Permianibacter aggregans]
TTGCCAACCCGTGACGAGAATATCTGGCAACGTTGCCGGGGCGCCGATTTTATTGGTCCGATGAAAGTCGAGATGGTGCG
CATTGTTGAGGCGCAGGAAGATATCGCGACCTTGTCGCTGGTCGATAACCTCGACGAGCAGCATTTGCTGGAATCGCTGC
TGGAAAAAAGCAAACCTGGCCAACTCGAGCCCAACCTCCATTACCTGTTGGCGTCACCTTTCCGCTATCCTCCGCTGCTC
TGGGGCAGTCGCTTTGGCCGCGCTCACGAACGGGCCTTGTTTTATGGCTCCACCCGCATGGAAACCGCGCTGGCCGAGTG
TGCGTTCTATCGATTGGTCTTTATCGATGGTGTTTCGGTGCCGTTTCCGCAACCGCTGGTTTCCCAACACACGAGTTTCT
GGGCGCTAGCCCGGGCCGAACGCGCAGCCGATCTAACCCGCTCACCGTACGACAGCGTCATGGCTGAACTGCGCGCACCT
GACCGCTATAGCGCCACCCAGATTCTGGGCAGCGAAATGCGTTCAGCGGGTGTCATGCTGTTCACCTACCGCTCGGCCCG
TGATGATGACCCGACCGCCATCAATGCGGCGGCATTCAGTCCGGACGTTTTCAAGCGTGCTCAACCGACTCGTTTTCAGA
GCTGGACGTGTTATGCCACCGCCGACGCCGTGCGTTTTATTTCCAGCCCAAACAAAGCCTCGCATGAATTTTCCCGCCAT
CGCTTTCTGGTCAACGAGCGCTTGCCGATGCCGCCGCCGGCGTAG

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13645.69 Da        Isoelectric Point: 8.8806

>AT120562 WP_133589195.1 NZ_CP037953:2700887-2701258 [Permianibacter aggregans]
MTAVHINQPDPGAVLCKALRRTQEAFELSNEELGKVIGKDRTTISRLYDKGYLSPDSKEGELATLLIRIYRGLYALVGGA
GENMQHWLNTPNQHLQGQPRELLRSVTGLVAVLGYLDAMRGRI

Download         Length: 372 bp

>AT120562 NZ_CP037953:2700887-2701258 [Permianibacter aggregans]
ATGACCGCTGTTCACATCAACCAACCCGATCCAGGCGCGGTACTGTGCAAAGCGCTACGCCGCACCCAAGAGGCCTTTGA
GCTCAGCAACGAGGAGCTTGGCAAGGTCATTGGCAAGGATCGGACGACGATTAGCCGGCTTTACGACAAAGGCTACCTTT
CGCCAGACAGCAAGGAAGGCGAGCTGGCTACGCTGCTGATCCGTATCTACCGAGGGCTATACGCCCTGGTTGGCGGTGCC
GGCGAGAACATGCAGCACTGGTTGAATACGCCAAACCAGCATCTGCAAGGGCAGCCACGTGAGTTACTGCGCTCGGTTAC
CGGCCTGGTGGCGGTACTGGGTTATTTGGACGCGATGCGCGGTCGTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References