Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 692974..694537 Replicon chromosome
Accession NZ_CP037953
Organism Permianibacter aggregans strain HW001

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag E2H98_RS03195 Protein ID WP_133587734.1
Coordinates 692974..694287 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag E2H98_RS03200 Protein ID WP_133587736.1
Coordinates 694277..694537 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E2H98_RS03180 689598..690218 - 621 WP_133587727.1 hypothetical protein -
E2H98_RS03185 690483..690968 + 486 WP_157591222.1 DUF4124 domain-containing protein -
E2H98_RS03190 691287..692465 + 1179 WP_133587732.1 lipid-transfer protein -
E2H98_RS03195 692974..694287 - 1314 WP_133587734.1 type II toxin-antitoxin system HipA family toxin Toxin
E2H98_RS03200 694277..694537 - 261 WP_133587736.1 helix-turn-helix transcriptional regulator Antitoxin
E2H98_RS03205 694804..695960 + 1157 WP_133587742.1 IS3 family transposase -
E2H98_RS03210 696219..696500 - 282 WP_133587745.1 zinc ribbon domain-containing protein -
E2H98_RS03215 697051..698772 + 1722 WP_133587747.1 proline--tRNA ligase -
E2H98_RS03220 698830..699456 + 627 WP_133588107.1 lytic transglycosylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-102)

Antitoxin

Transcription regulator, HipB-like

(8-64)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 48041.06 Da        Isoelectric Point: 5.6253

>T120561 WP_133587734.1 NZ_CP037953:c694287-692974 [Permianibacter aggregans]
MAHELAVWLFEECVGTLAMSDGRLNFAYLPEWLSRANAIALSASLPLRAEPFDDAKVRPFFAGLLPEGQLRRLIAQQFQV
SDQNDFALLDRLGGDCAGAVALLPPGHALPDSAHDAQVEWLDDKQVIAILDELPRRPMLAGRDGLRLSLAGAQDKLPVVF
DGERIGLPRDGTPSSHILKPAIDAIDAIDAIDAIDAIEDSVINEGFCMALADAMQLAVAKATIHTISNRSFLLVARYDRV
VDGQGHRMRVHQEDFCQALGVVPEMKYQNEGGPDLAQCFELVRRVTRPNAPQVLRLLDQVMFNALIGNHDAHGKNFSLLY
SAERANHAAVLSPAYDLLSTAVYPELTPKMAMKIGSKYKFSEVQARHWEQLAESAGLSKPQTKKRLLEFASALPQTAREV
QAGNARLFVGNALVGRIIELIEQRCEQTIRRFSLAAE

Download         Length: 1314 bp

>T120561 NZ_CP037953:c694287-692974 [Permianibacter aggregans]
ATGGCGCATGAACTGGCGGTATGGCTTTTTGAAGAATGTGTCGGCACCTTGGCGATGAGTGATGGCCGGCTAAATTTTGC
TTACCTGCCGGAGTGGCTTTCACGTGCCAATGCGATTGCCTTGTCGGCGTCGTTACCTTTGCGAGCGGAACCGTTTGATG
ATGCAAAAGTGCGCCCTTTTTTCGCCGGCTTGTTGCCAGAAGGGCAGTTGCGTCGTTTGATTGCGCAACAGTTTCAGGTG
TCTGACCAAAATGATTTTGCATTGCTGGATCGTCTTGGTGGTGATTGCGCGGGGGCCGTGGCGCTGCTGCCGCCCGGACA
CGCGTTGCCGGATTCAGCCCACGATGCTCAGGTTGAATGGCTTGATGATAAGCAGGTAATTGCCATTCTTGATGAATTAC
CGCGTCGGCCGATGCTGGCCGGCAGAGACGGTTTGCGACTGTCGTTAGCCGGTGCGCAAGATAAATTGCCGGTGGTGTTT
GATGGTGAACGAATTGGCTTGCCTCGCGATGGCACACCGAGCTCTCATATTTTGAAACCTGCCATTGATGCCATTGATGC
CATTGATGCCATTGATGCCATTGATGCCATTGAAGATAGTGTGATCAATGAAGGTTTCTGTATGGCGCTGGCTGACGCGA
TGCAACTTGCGGTGGCCAAAGCGACGATTCACACGATATCAAATCGTTCGTTTTTATTGGTTGCGCGTTACGACCGTGTA
GTGGATGGGCAAGGGCACAGAATGCGCGTTCACCAGGAAGATTTCTGCCAGGCGCTGGGTGTCGTGCCGGAAATGAAGTA
TCAAAACGAAGGTGGCCCGGACTTGGCTCAGTGCTTTGAGCTGGTGCGGCGTGTTACTCGCCCCAATGCGCCGCAGGTTC
TGCGATTGCTGGACCAGGTGATGTTTAATGCCTTGATTGGTAACCATGATGCGCATGGCAAGAATTTTTCACTGCTGTAT
TCCGCTGAACGCGCAAATCACGCCGCGGTGCTCTCTCCGGCTTATGATTTATTGTCAACAGCGGTGTACCCGGAACTAAC
GCCGAAGATGGCCATGAAAATTGGTAGCAAGTATAAATTCAGCGAAGTGCAAGCGCGACATTGGGAGCAGTTGGCCGAAT
CGGCTGGGTTATCGAAACCGCAAACCAAGAAGCGGCTGTTGGAGTTTGCTAGCGCATTACCACAAACCGCTCGCGAGGTT
CAGGCGGGTAATGCAAGACTCTTCGTAGGTAATGCGTTGGTCGGGCGCATTATTGAGCTGATTGAGCAGCGGTGCGAGCA
AACTATTCGACGGTTTTCTCTTGCTGCGGAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 8991.24 Da        Isoelectric Point: 6.2096

>AT120561 WP_133587736.1 NZ_CP037953:c694537-694277 [Permianibacter aggregans]
MTIIRTAEQLGSALRAARKHLSLTQPQLALAAGVGVRFIVDLEAGKPTLRLENVLRVIDALGGEVQLTGLPSGADGNHDE
ADQHGA

Download         Length: 261 bp

>AT120561 NZ_CP037953:c694537-694277 [Permianibacter aggregans]
ATGACCATTATTCGAACCGCTGAGCAGCTTGGTAGCGCGCTTCGCGCTGCCCGCAAGCATTTATCACTGACCCAACCCCA
ACTGGCCTTGGCTGCCGGGGTAGGCGTGCGTTTTATCGTTGACCTGGAGGCTGGCAAGCCGACGTTGCGGCTGGAAAACG
TGCTGCGCGTTATTGATGCGCTGGGTGGCGAAGTTCAGTTGACTGGTTTGCCTTCCGGCGCTGACGGTAACCATGATGAG
GCGGATCAGCATGGCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References