Detailed information of TA system TA120558

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 3721204..3721690
• Replicon: chromosome
• Accession: NZ_CP037952
• Organism: Parashewanella spongiae strain HJ039

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E2I05_RS14725
• Protein ID: WP_121854537.1
• Coordinates: 3721204..3721476 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: E2I05_RS14730
• Protein ID: WP_121854538.1
• Coordinates: 3721478..3721690 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E2I05_RS14700	3716519..3717139	-	621	WP_121854532.1	type IV secretion protein	-
E2I05_RS14705	3717136..3719598	-	2463	WP_121854533.1	VirB4 family type IV secretion/conjugal transfer ATPase	-
E2I05_RS14710	3719595..3719918	-	324	WP_121854534.1	VirB3 family type IV secretion system protein	-
E2I05_RS14715	3719929..3720267	-	339	WP_121854535.1	TrbC/VirB2 family protein	-
E2I05_RS14720	3720548..3721186	+	639	WP_121854536.1	hypothetical protein	-
E2I05_RS14725	3721204..3721476	-	273	WP_121854537.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E2I05_RS14730	3721478..3721690	-	213	WP_121854538.1	TraY domain-containing protein	Antitoxin
E2I05_RS14735	3722030..3723535	+	1506	WP_133309665.1	transposase	-
E2I05_RS14740	3723808..3724443	-	636	WP_121855320.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Relaxosome protein TraY (3-39)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10828.64 Da
• Isoelectric Point: 10.4613

>T120558 WP_121854537.1 NZ_CP037952:c3721476-3721204 [Parashewanella spongiae]
MAQWQIEWDSRALKELKKLDKQVQKDIIHYLKTRISTEESPRRFGKALLGNKAGLWRYRVKNYRIICNIEDDTLVVLVLR
TSHRKDVYQL

Nucleotide

• Length: 273 bp

>T120558 NZ_CP037952:c3721476-3721204 [Parashewanella spongiae]
ATGGCGCAGTGGCAAATCGAATGGGACAGCCGTGCCCTGAAGGAGCTGAAAAAGCTCGATAAACAAGTGCAAAAAGATAT
CATTCACTACCTTAAAACCCGTATCTCCACCGAGGAATCGCCACGACGTTTTGGTAAAGCCCTGTTAGGTAATAAAGCCG
GATTGTGGCGTTATAGAGTCAAAAACTATCGCATTATTTGCAATATCGAAGACGACACTTTAGTGGTGTTGGTGCTACGA
ACTAGCCATCGTAAAGATGTATATCAGTTGTAA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7979.04 Da
• Isoelectric Point: 4.4367

>AT120558 WP_121854538.1 NZ_CP037952:c3721690-3721478 [Parashewanella spongiae]
MLSLRLSDSIEQRLNQLAETTGRTKSFYAKEAIAKYLDEMEDKYIAISRLENPAPRVSMADVEKELGLDD

Nucleotide

• Length: 213 bp

>AT120558 NZ_CP037952:c3721690-3721478 [Parashewanella spongiae]
ATGTTATCACTCAGATTATCTGACAGCATCGAGCAGCGTTTAAACCAGTTGGCGGAAACTACTGGCCGCACCAAATCTTT
TTATGCCAAAGAAGCTATTGCAAAATACCTTGATGAGATGGAAGACAAGTACATCGCCATTAGCCGTCTTGAAAATCCAG
CTCCCCGGGTTTCAATGGCCGATGTGGAAAAAGAATTGGGCTTAGACGATTAA