Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 3556621..3557384 Replicon chromosome
Accession NZ_CP037952
Organism Parashewanella spongiae strain HJ039

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag E2I05_RS13980 Protein ID WP_121855018.1
Coordinates 3556621..3557115 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag E2I05_RS13985 Protein ID WP_121855019.1
Coordinates 3557112..3557384 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E2I05_RS13955 3552074..3552676 - 603 WP_121855015.1 mobile mystery protein B -
E2I05_RS13960 3552673..3553185 - 513 WP_121855023.1 mobile mystery protein A -
E2I05_RS13965 3553558..3553989 - 432 WP_121855016.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
E2I05_RS13970 3554545..3555348 - 804 WP_121855017.1 DUF3307 domain-containing protein -
E2I05_RS13975 3555341..3556003 - 663 WP_121855024.1 hypothetical protein -
E2I05_RS13980 3556621..3557115 - 495 WP_121855018.1 GNAT family N-acetyltransferase Toxin
E2I05_RS13985 3557112..3557384 - 273 WP_121855019.1 DUF1778 domain-containing protein Antitoxin
E2I05_RS13990 3557688..3557846 - 159 WP_121855020.1 hypothetical protein -
E2I05_RS13995 3557887..3559398 - 1512 WP_121855021.1 Fic family protein -
E2I05_RS14000 3559501..3559941 + 441 WP_121855022.1 zeta toxin family protein -
E2I05_RS14005 3560179..3561459 - 1281 Protein_2734 transposase -
E2I05_RS14010 3561947..3562318 + 372 WP_121855239.1 DUF3596 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-151)

Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18459.41 Da        Isoelectric Point: 10.1557

>T120556 WP_121855018.1 NZ_CP037952:c3557115-3556621 [Parashewanella spongiae]
MNVVLLDKAKHDRKRFNCGVEVLNNYVKVMASQQAKKDNSRTFVLEDELEPSHIIGFYTLTMTPIDLKALPDKLQKKHQP
STSGGLIARLSVDQRYKGKGFGEWLLIDALRKLLSASDSVVFPFVIVNAKDGAKQFYERYGFAAFKDAGNKLFITISDVR
KSMG

Download         Length: 495 bp

>T120556 NZ_CP037952:c3557115-3556621 [Parashewanella spongiae]
ATGAATGTGGTCTTGCTCGATAAAGCAAAACACGATCGTAAGCGCTTTAATTGCGGCGTAGAAGTGTTAAACAACTATGT
AAAAGTGATGGCAAGTCAACAAGCCAAAAAGGACAACAGCAGAACTTTTGTGCTTGAAGATGAGCTGGAGCCATCACACA
TCATCGGCTTTTACACGCTAACCATGACCCCGATAGACCTAAAAGCCTTACCTGACAAACTCCAAAAGAAACACCAACCT
TCAACGTCAGGCGGGTTAATCGCACGTCTTTCAGTCGATCAACGTTACAAAGGCAAAGGGTTTGGTGAATGGTTGCTGAT
CGACGCCTTGCGAAAACTGTTATCAGCTAGTGATAGCGTAGTCTTTCCTTTTGTGATAGTTAATGCCAAAGACGGTGCCA
AGCAATTTTATGAACGCTATGGGTTCGCTGCCTTTAAGGATGCTGGAAATAAGCTGTTTATCACTATTTCTGACGTCAGA
AAAAGCATGGGCTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9853.39 Da        Isoelectric Point: 9.1431

>AT120556 WP_121855019.1 NZ_CP037952:c3557384-3557112 [Parashewanella spongiae]
MPTTLPRITARVDIDTQDLLAKAAAIAGMSSINSFVLNAAIERAKQVIEREQSLKLSQADAMQLMEALDRPAQVRTKLQT
AAQCYHGKTQ

Download         Length: 273 bp

>AT120556 NZ_CP037952:c3557384-3557112 [Parashewanella spongiae]
ATGCCAACAACATTACCTCGTATCACCGCCAGAGTGGATATTGATACACAAGATTTACTAGCCAAGGCCGCAGCGATAGC
GGGTATGTCCAGTATTAATTCATTTGTGTTAAATGCGGCCATTGAAAGAGCCAAACAAGTGATTGAACGTGAACAATCGC
TTAAGCTCAGTCAAGCCGATGCTATGCAGTTGATGGAAGCGTTAGACCGTCCAGCGCAGGTACGCACCAAGTTGCAAACC
GCAGCCCAGTGCTATCATGGGAAAACACAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References