Detailed information of TA system TA120555

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 2947843..2948378
• Replicon: chromosome
• Accession: NZ_CP037952
• Organism: Parashewanella spongiae strain HJ039

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E2I05_RS11505
• Protein ID: WP_121854404.1
• Coordinates: 2947843..2948118 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: E2I05_RS11510
• Protein ID: WP_121854405.1
• Coordinates: 2948118..2948378 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E2I05_RS11500	2943681..2947691	+	4011	WP_133309647.1	hypothetical protein	-
E2I05_RS11505	2947843..2948118	-	276	WP_121854404.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E2I05_RS11510	2948118..2948378	-	261	WP_121854405.1	ribbon-helix-helix domain-containing protein	Antitoxin
E2I05_RS11515	2948539..2948628	+	90	WP_165905534.1	helix-turn-helix domain-containing protein	-
E2I05_RS11520	2949009..2950118	-	1110	WP_121854407.1	3-phosphoserine/phosphohydroxythreonine transaminase	-
E2I05_RS11525	2950183..2952888	-	2706	WP_121854408.1	DNA gyrase subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10881.48 Da
• Isoelectric Point: 10.0320

>T120555 WP_121854404.1 NZ_CP037952:c2948118-2947843 [Parashewanella spongiae]
MQIKWTSKSASDLSRLFEFLAYVNRNTAAKTVQTLVDAPNRLIQQPFIGERLDSFTDRDVRRLIISSYEMRYEVTDDVLF
ILRIWHTREKR

Nucleotide

• Length: 276 bp

>T120555 NZ_CP037952:c2948118-2947843 [Parashewanella spongiae]
ATGCAAATCAAATGGACAAGTAAATCAGCCTCCGATTTGAGTAGGTTATTTGAATTTTTAGCTTACGTTAATCGAAATAC
AGCAGCCAAAACAGTACAAACTTTGGTTGATGCTCCAAATCGGCTCATCCAACAGCCATTTATTGGAGAGAGACTTGATT
CATTTACTGACCGTGACGTTCGTAGACTAATCATTAGTAGCTATGAAATGCGGTATGAAGTGACTGACGACGTTCTTTTT
ATCCTTCGAATTTGGCATACTCGAGAGAAAAGATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9752.07 Da
• Isoelectric Point: 4.8134

>AT120555 WP_121854405.1 NZ_CP037952:c2948378-2948118 [Parashewanella spongiae]
MDTKVITAHVPVPLAEKVDLLANRLERSKAWIMKQALAAWIDQEEERHKLTLEALADVDNNNVIEHQSMLDWAQSLDTDK
SKSVTS

Nucleotide

• Length: 261 bp

>AT120555 NZ_CP037952:c2948378-2948118 [Parashewanella spongiae]
ATGGACACTAAAGTTATTACCGCCCATGTTCCAGTTCCGTTAGCTGAGAAGGTTGATCTTTTAGCTAATAGATTAGAACG
GTCGAAGGCATGGATCATGAAACAAGCTTTAGCCGCTTGGATTGATCAAGAAGAAGAGAGGCATAAGTTAACATTAGAAG
CGCTAGCTGATGTTGATAACAATAATGTTATAGAACACCAATCAATGCTTGATTGGGCACAAAGTCTAGATACTGATAAA
TCCAAATCAGTTACAAGTTAA